Abstract：
Chronic prostatitis is a highly prevalent condition that significantly impacts the quality of life and fertility of men. Because of its heterogeneous nature, there is no definitive treatment, which requires ongoing research into its etiology. Additionally, the association between prostatitis and an elevated risk of prostate cancer highlights the importance of comprehending androgen involvement in prostatitis. This paper examines the current understanding of androgen signaling in prostatitis and explores contemporary therapeutic approaches. It was reviewed Medline articles comprehensively, using keywords such as nonbacterial prostatitis, prostatitis infertility, androgen role in prostatitis, and chronic pelvic pain. Several cellular targets are linked to androgen signaling. Notably, the major tyrosine phosphatase activity (cPAcP) in normal human prostate is influenced by androgen signaling, and its serum levels inversely correlate with prostate cancer progression. Androgens also regulate membrane-associated zinc and pyruvate transporters transduction in prostate cells, suggesting promising avenues for novel drug development aimed at inhibiting these molecules to reduce cancer tumor growth. Various therapies for prostatitis have been evaluated, including antibiotics, anti-inflammatory medications (including bioflavonoids), neuromodulators, alpha-blockers, 5α-reductase inhibitors, and androgen receptor antagonists. These therapies have demonstrated varying degrees of success in ameliorating symptoms.In conclusion, aging decreases circulating T and intraprostatic DHT, altering the proper functioning of the prostate, reducing the ability of androgens to maintain normal Zn2+ levels, and diminishing the secretion of citrate, PAcP, and other proteins into the prostatic fluid. The Zn2+-transporter decreases or is absent in prostate cancer, so the pyruvate transporter activates. Consequently, the cell ATP increases, inducing tumor growth.
摘要：
慢性前列腺炎是一种非常普遍的疾病，严重影响男性的生活质量和生育能力。由于其异质性，没有明确的治疗方法,这需要对其病因进行持续的研究。此外,前列腺炎与前列腺癌风险升高之间的关联凸显了了解雄激素参与前列腺炎的重要性。本文探讨了当前对前列腺炎中雄激素信号传导的理解，并探讨了当代的治疗方法。全面审查了Medline的文章，使用关键词，如非细菌性前列腺炎，前列腺炎不孕症，雄激素在前列腺炎中的作用，和慢性盆腔疼痛.几种细胞靶标与雄激素信号传导有关。值得注意的是,正常人前列腺中主要的酪氨酸磷酸酶活性（cPAcP）受雄激素信号的影响，其血清水平与前列腺癌进展呈负相关。雄激素还调节前列腺细胞中膜相关锌和丙酮酸转运蛋白的转导，为新药开发提供了有希望的途径，旨在抑制这些分子以减少癌症肿瘤的生长。已经评估了前列腺炎的各种疗法，包括抗生素,抗炎药（包括生物类黄酮），神经调质，α-受体阻滞剂,5α-还原酶抑制剂，和雄激素受体拮抗剂.这些疗法在改善症状方面已显示出不同程度的成功。总之,衰老降低循环T和前列腺内DHT，改变前列腺的正常功能，降低雄激素维持正常Zn2+水平的能力，减少柠檬酸盐的分泌，PAcP,和其他蛋白质进入前列腺液。前列腺癌中Zn2+转运体减少或缺失，所以丙酮酸运输机启动了。因此,细胞ATP增加，诱导肿瘤生长。
