Abstract：
OBJECTIVE: To compare the tensile strength of fast absorbable Polyglactin 910 suture material when impregnated with various agents for local anesthesia and to investigate whether the presence of ethanol in Xylocaine spray could explain a potential reduction in tensile strength after use of Xylocaine spray.
METHODS: In all, 120 suture samples of Polyglactin 910 were divided into four groups of 30. These four groups were randomly impregnated with isotonic sodium chloride, isotonic sodium chloride plus Xylocaine spray, isotonic sodium chloride plus Xylocaine gel, or isotonic sodium chloride plus ethanol. After impregnation, the sutures were stored in sealed glass tubes in a heating cabinet at 37°C for 72 h. Thereafter, the tensile strength of these 120 samples was assessed by a universal tensile testing machine. The maximal force needed to break the suture material was recorded in newtons (N).
RESULTS: Fast absorbable Polyglactin 910 suture material impregnated with Xylocaine spray or ethanol showed weakened tensile strength (mean values 11.40 and 11.86 N, respectively), whereas the specimens impregnated with Xylocaine gel or sodium chloride retained their tensile strength better (mean values 13.81 and 13.28 N, respectively; mean difference between Xylocaine gel and Xylocaine spray -2.41 N, P < 0.001).
CONCLUSIONS: In this in vitro experiment, ethanol and Xylocaine spray weakened the tensile strength of fast absorbable Polyglactin 910 sutures. Use of Xylocaine spray, which contains ethanol, for local anesthesia might lead to early breakdown of the suture material and wound rupture. The authors suggest caution when using Xylocaine spray in combination with fast absorbable Polyglactin 910 suture.
METHODS: In all, 120 suture samples of Polyglactin 910 were divided into four groups of 30. These four groups were randomly impregnated with isotonic sodium chloride, isotonic sodium chloride plus Xylocaine spray, isotonic sodium chloride plus Xylocaine gel, or isotonic sodium chloride plus ethanol. After impregnation, the sutures were stored in sealed glass tubes in a heating cabinet at 37°C for 72 h. Thereafter, the tensile strength of these 120 samples was assessed by a universal tensile testing machine. The maximal force needed to break the suture material was recorded in newtons (N).
RESULTS: Fast absorbable Polyglactin 910 suture material impregnated with Xylocaine spray or ethanol showed weakened tensile strength (mean values 11.40 and 11.86 N, respectively), whereas the specimens impregnated with Xylocaine gel or sodium chloride retained their tensile strength better (mean values 13.81 and 13.28 N, respectively; mean difference between Xylocaine gel and Xylocaine spray -2.41 N, P < 0.001).
CONCLUSIONS: In this in vitro experiment, ethanol and Xylocaine spray weakened the tensile strength of fast absorbable Polyglactin 910 sutures. Use of Xylocaine spray, which contains ethanol, for local anesthesia might lead to early breakdown of the suture material and wound rupture. The authors suggest caution when using Xylocaine spray in combination with fast absorbable Polyglactin 910 suture.
摘要：
目的：比较可快速吸收的Polyglactin910缝合材料在局部麻醉中浸渍各种药剂时的拉伸强度，并研究在使用Xylocaine喷雾剂后乙醇的存在是否可以解释拉伸强度的潜在降低。
方法：总之，将120个Polyglactin910的缝合线样品分成四组,每组30个。这四组随机浸渍等渗氯化钠,等渗氯化钠加木卡因喷雾剂，等渗氯化钠加木卡因凝胶，或者等渗氯化钠加乙醇.浸渍后，将缝合线在37°C的加热箱中的密封玻璃管中储存72小时。这120个样品的拉伸强度通过万能拉伸试验机进行评估。以牛顿(N)记录断裂缝合材料所需的最大力。
结果：用西卡因喷雾剂或乙醇浸渍的快速可吸收的Polyglactin910缝合材料显示出减弱的拉伸强度（平均值11.40和11.86N，分别)，而浸渍有Xylocaine凝胶或氯化钠的样品保留了其拉伸强度更好（平均值13.81和13.28N，分别为：Xylocaine凝胶和Xylocaine喷雾剂的平均差-2.41N，P<0.001)。
结论：在这个体外实验中，乙醇和Xylocaine喷雾削弱了快速可吸收的Polyglactin910缝合线的拉伸强度。使用Xylocaine喷雾剂，含有乙醇，局部麻醉可能导致缝合材料早期破裂和伤口破裂。作者建议谨慎使用Xylocaine喷雾剂与快速可吸收的Polyglactin910缝合线结合使用。
方法：总之，将120个Polyglactin910的缝合线样品分成四组,每组30个。这四组随机浸渍等渗氯化钠,等渗氯化钠加木卡因喷雾剂，等渗氯化钠加木卡因凝胶，或者等渗氯化钠加乙醇.浸渍后，将缝合线在37°C的加热箱中的密封玻璃管中储存72小时。这120个样品的拉伸强度通过万能拉伸试验机进行评估。以牛顿(N)记录断裂缝合材料所需的最大力。
结果：用西卡因喷雾剂或乙醇浸渍的快速可吸收的Polyglactin910缝合材料显示出减弱的拉伸强度（平均值11.40和11.86N，分别)，而浸渍有Xylocaine凝胶或氯化钠的样品保留了其拉伸强度更好（平均值13.81和13.28N，分别为：Xylocaine凝胶和Xylocaine喷雾剂的平均差-2.41N，P<0.001)。
结论：在这个体外实验中，乙醇和Xylocaine喷雾削弱了快速可吸收的Polyglactin910缝合线的拉伸强度。使用Xylocaine喷雾剂，含有乙醇，局部麻醉可能导致缝合材料早期破裂和伤口破裂。作者建议谨慎使用Xylocaine喷雾剂与快速可吸收的Polyglactin910缝合线结合使用。
