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Abstract：
OBJECTIVE: Respiratory complications in Cystic Fibrosis (CF) are still the leading cause of death nowadays in these patients. High-Resolution Computed Tomography is the gold standard method for staging lung disease in CF. In this study we assessed lung ultrasound findings in asymptomatic preschool patients affected by CF.
METHODS: This is a case-control study with a total of 70 enrolled patients (20 patients affected by CF, 50 healthy controls) aged from 31 to 6 years. All included patients were without intercurrent lung problems and without antibiotic therapy in the last 30 days. For each patient a lung Point of Care Ultrasound (POCUS) of lung was performed.
RESULTS: B lines < 3 and sub-pleural consolidations < 1 cm were statistically more frequent in CF patients, both in terms of number of affected patients (p 0.02 and p 0.0001 respectively) and frequency (p 0.0181 and p 0.0001 respectively); the prevalence of B lines < 3 in control group was high (47.73%) however the prevalence of sub-pleural consolidations was very low (2.27%). In both groups coalescent B lines affected a greater number of infants and were in higher number of findings than patients aged between 2 and 6 years.
CONCLUSIONS: The presence of multiple subpleural pulmonary consolidations < 1 cm in asymptomatic preschool children could be a ultrasound markers of subclinical pulmonary disease such as CF. POCUS of lung is confirmed as a useful tool for the clinician as confirmation of a clinical suspicion, help reduce the use of ionizing radiation.
METHODS: This is a case-control study with a total of 70 enrolled patients (20 patients affected by CF, 50 healthy controls) aged from 31 to 6 years. All included patients were without intercurrent lung problems and without antibiotic therapy in the last 30 days. For each patient a lung Point of Care Ultrasound (POCUS) of lung was performed.
RESULTS: B lines < 3 and sub-pleural consolidations < 1 cm were statistically more frequent in CF patients, both in terms of number of affected patients (p 0.02 and p 0.0001 respectively) and frequency (p 0.0181 and p 0.0001 respectively); the prevalence of B lines < 3 in control group was high (47.73%) however the prevalence of sub-pleural consolidations was very low (2.27%). In both groups coalescent B lines affected a greater number of infants and were in higher number of findings than patients aged between 2 and 6 years.
CONCLUSIONS: The presence of multiple subpleural pulmonary consolidations < 1 cm in asymptomatic preschool children could be a ultrasound markers of subclinical pulmonary disease such as CF. POCUS of lung is confirmed as a useful tool for the clinician as confirmation of a clinical suspicion, help reduce the use of ionizing radiation.
摘要：
目的：囊性纤维化（CF）的呼吸系统并发症仍然是目前这些患者的主要死亡原因。高分辨率计算机断层扫描是CF中肺部疾病分期的金标准方法。在这项研究中，我们评估了受CF影响的无症状学龄前患者的肺部超声检查结果。
方法：这是一项病例对照研究，共纳入70例患者（20例受CF影响的患者，50名健康对照）年龄从31岁到6岁。所有纳入的患者在最近30天内没有并发肺部问题，也没有抗生素治疗。对于每位患者,进行肺的肺护理点超声(POCUS)。
结果：在CF患者中，B线<3和胸膜下合并<1cm的发生率更高，就受影响的患者数量（分别为p0.02和p0.0001）和频率（分别为p0.0181和p0.0001）而言；对照组中B线<3的患病率很高（47.73％），而胸膜下合并的患病率很低（2.27％）。在两组中，合并B系影响了更多的婴儿，并且发现数量高于2至6岁的患者。
结论：在无症状的学龄前儿童中存在多个<1cm的胸膜下肺实变可能是亚临床肺部疾病如CF的超声标志物。肺的POCUS被确认为临床医生的有用工具，作为临床怀疑的确认，帮助减少电离辐射的使用。
方法：这是一项病例对照研究，共纳入70例患者（20例受CF影响的患者，50名健康对照）年龄从31岁到6岁。所有纳入的患者在最近30天内没有并发肺部问题，也没有抗生素治疗。对于每位患者,进行肺的肺护理点超声(POCUS)。
结果：在CF患者中，B线<3和胸膜下合并<1cm的发生率更高，就受影响的患者数量（分别为p0.02和p0.0001）和频率（分别为p0.0181和p0.0001）而言；对照组中B线<3的患病率很高（47.73％），而胸膜下合并的患病率很低（2.27％）。在两组中，合并B系影响了更多的婴儿，并且发现数量高于2至6岁的患者。
结论：在无症状的学龄前儿童中存在多个<1cm的胸膜下肺实变可能是亚临床肺部疾病如CF的超声标志物。肺的POCUS被确认为临床医生的有用工具，作为临床怀疑的确认，帮助减少电离辐射的使用。
