METHODS: This is a case-control study with a total of 70 enrolled patients (20 patients affected by CF, 50 healthy controls) aged from 31 to 6 years. All included patients were without intercurrent lung problems and without antibiotic therapy in the last 30 days. For each patient a lung Point of Care Ultrasound (POCUS) of lung was performed.
RESULTS: B lines < 3 and sub-pleural consolidations < 1 cm were statistically more frequent in CF patients, both in terms of number of affected patients (p 0.02 and p 0.0001 respectively) and frequency (p 0.0181 and p 0.0001 respectively); the prevalence of B lines < 3 in control group was high (47.73%) however the prevalence of sub-pleural consolidations was very low (2.27%). In both groups coalescent B lines affected a greater number of infants and were in higher number of findings than patients aged between 2 and 6 years.
CONCLUSIONS: The presence of multiple subpleural pulmonary consolidations < 1 cm in asymptomatic preschool children could be a ultrasound markers of subclinical pulmonary disease such as CF. POCUS of lung is confirmed as a useful tool for the clinician as confirmation of a clinical suspicion, help reduce the use of ionizing radiation.
方法:这是一项病例对照研究,共纳入70例患者(20例受CF影响的患者,50名健康对照)年龄从31岁到6岁。所有纳入的患者在最近30天内没有并发肺部问题,也没有抗生素治疗。对于每位患者,进行肺的肺护理点超声(POCUS)。
结果:在CF患者中,B线<3和胸膜下合并<1cm的发生率更高,就受影响的患者数量(分别为p0.02和p0.0001)和频率(分别为p0.0181和p0.0001)而言;对照组中B线<3的患病率很高(47.73%),而胸膜下合并的患病率很低(2.27%)。在两组中,合并B系影响了更多的婴儿,并且发现数量高于2至6岁的患者。
结论:在无症状的学龄前儿童中存在多个<1cm的胸膜下肺实变可能是亚临床肺部疾病如CF的超声标志物。肺的POCUS被确认为临床医生的有用工具,作为临床怀疑的确认,帮助减少电离辐射的使用。