%0 Journal Article
%T Point of care lung ultrasound in preschool children with cystic fibrosis: a case-controlled, prospective, pilot study.
%A Crispino AA
%A Musolino AM
%A Buonsenso D
%A Caloiero M
%A Concolino D
%J J Ultrasound
%V 27
%N 2
%D 2024 Jun 19
%M 38240960
暂无%R 10.1007/s40477-023-00841-0
%X <B>OBJECTIVE: </B>Respiratory complications in Cystic Fibrosis (CF) are still the leading cause of death nowadays in these patients. High-Resolution Computed Tomography is the gold standard method for staging lung disease in CF. In this study we assessed lung ultrasound findings in asymptomatic preschool patients affected by CF.<BR><B>METHODS: </B>This is a case-control study with a total of 70 enrolled patients (20 patients affected by CF, 50 healthy controls) aged from 31 to 6 years. All included patients were without intercurrent lung problems and without antibiotic therapy in the last 30 days. For each patient a lung Point of Care Ultrasound (POCUS) of lung was performed.<BR><B>RESULTS: </B>B lines < 3 and sub-pleural consolidations < 1 cm were statistically more frequent in CF patients, both in terms of number of affected patients (p 0.02 and p 0.0001 respectively) and frequency (p 0.0181 and p 0.0001 respectively); the prevalence of B lines < 3 in control group was high (47.73%) however the prevalence of sub-pleural consolidations was very low (2.27%). In both groups coalescent B lines affected a greater number of infants and were in higher number of findings than patients aged between 2 and 6 years.<BR><B>CONCLUSIONS: </B>The presence of multiple subpleural pulmonary consolidations < 1 cm in asymptomatic preschool children could be a ultrasound markers of subclinical pulmonary disease such as CF. POCUS of lung is confirmed as a useful tool for the clinician as confirmation of a clinical suspicion, help reduce the use of ionizing radiation.