PDF(Pubmed)
Abstract：
Bone marrow stromal cell antigen 2 (BST2) is a type II transmembrane protein that serves critical roles in antiretroviral defense in the innate immune response. In addition, it has been suggested that BST2 is highly expressed in various types of human cancer and high BST2 expression is related to different clinicopathological parameters in cancer. The molecular mechanism underlying BST2 as a potential tumor biomarker in human solid tumors has been reported on; however, to the best of our knowledge, there has been no review published on the molecular mechanism of BST2 in human solid tumors. The present review focuses on human BST2 expression, structure and functions; the molecular mechanisms of BST2 in breast cancer, hepatocellular carcinoma, gastrointestinal tumor and other solid tumors; the therapeutic potential of BST2; and the possibility of BST2 as a potential marker. BST2 is involved in cell membrane integrity and lipid raft formation, which can activate epidermal growth factor receptor signaling pathways, providing a potential mechanistic link between BST2 and tumorigenesis. Notably, BST2 may be considered a universal tumor biomarker and a potential therapeutical target.
摘要：
骨髓基质细胞抗原2（BST2）是一种II型跨膜蛋白，在先天免疫应答中的抗逆转录病毒防御中起关键作用。此外,已提示BST2在各种类型的人类癌症中高表达,并且高表达BST2与癌症的不同临床病理参数有关。BST2作为人类实体瘤中潜在肿瘤生物标志物的分子机制已被报道；然而，据我们所知,关于BST2在人类实体瘤中的分子机制尚未发表评论。本综述集中在人BST2表达，结构和功能；BST2在乳腺癌中的分子机制，肝细胞癌，胃肠道肿瘤和其他实体瘤;BST2的治疗潜力;以及BST2作为潜在标志物的可能性。BST2参与细胞膜完整性和脂筏形成，可以激活表皮生长因子受体信号通路，在BST2和肿瘤发生之间提供潜在的机制联系。值得注意的是,BST2可以被认为是通用的肿瘤生物标志物和潜在的治疗靶标。
