PDF(Pubmed)
Abstract：
UNASSIGNED: Considering the numerous drug resistance in cancer and the advancement of science in nanomedicines, it was decided to compare the effectiveness of zinc oxide nanoparticles in colon and prostate cell lines. Considering the importance of factors and Oxidative stress pathways in cancer prevention, the aim of the study is based on oxidative stress mechanisms.
UNASSIGNED: In order to evaluate the effects of zinc oxide nanoparticles on colon and prostate cell lines, oxidative stress factors ROS, MDA, and GSH and mitochondrial function were evaluated. The data was analyzed with Prism v8 software, and the significance level was considered to be P < 0.05.
UNASSIGNED: The results showed that nanoparticles induce ROS and reduce intracellular glutathione by destroying and disrupting mitochondrial function, and by increasing ROS production, damage to the lipid membrane and an increase in MDA were also evident. This effect was dose-dependent and the greatest at a concentration of 25 μg/mL. Also, ZnO nanoparticles performed better in the HT29 cell line than in the PC3 cell line.
UNASSIGNED: This study showed that exposure of HT29 and PC3 cancer cells to zinc oxide nanoparticles at different concentrations inhibited growth by cytotoxic effects.
UNASSIGNED: In order to evaluate the effects of zinc oxide nanoparticles on colon and prostate cell lines, oxidative stress factors ROS, MDA, and GSH and mitochondrial function were evaluated. The data was analyzed with Prism v8 software, and the significance level was considered to be P < 0.05.
UNASSIGNED: The results showed that nanoparticles induce ROS and reduce intracellular glutathione by destroying and disrupting mitochondrial function, and by increasing ROS production, damage to the lipid membrane and an increase in MDA were also evident. This effect was dose-dependent and the greatest at a concentration of 25 μg/mL. Also, ZnO nanoparticles performed better in the HT29 cell line than in the PC3 cell line.
UNASSIGNED: This study showed that exposure of HT29 and PC3 cancer cells to zinc oxide nanoparticles at different concentrations inhibited growth by cytotoxic effects.
摘要：
■考虑到癌症中的众多耐药性和纳米医学科学的进步，决定比较氧化锌纳米颗粒在结肠和前列腺细胞系中的有效性。考虑到因素和氧化应激途径在癌症预防中的重要性，这项研究的目的是基于氧化应激机制。
■为了评估氧化锌纳米颗粒对结肠和前列腺细胞系的影响，氧化应激因子ROS，MDA,并对GSH和线粒体功能进行评价。数据用Prismv8软件进行分析,显著性水平为P<0.05。
■结果表明，纳米颗粒通过破坏和破坏线粒体功能来诱导ROS并减少细胞内谷胱甘肽，通过增加ROS产量，脂质膜的损伤和MDA的增加也很明显。这种作用是剂量依赖性的,并且在25μg/mL的浓度下最大。此外，ZnO纳米颗粒在HT29细胞系中的表现优于在PC3细胞系中的表现。
■这项研究表明，将HT29和PC3癌细胞暴露于不同浓度的氧化锌纳米颗粒通过细胞毒性作用抑制了生长。
■为了评估氧化锌纳米颗粒对结肠和前列腺细胞系的影响，氧化应激因子ROS，MDA,并对GSH和线粒体功能进行评价。数据用Prismv8软件进行分析,显著性水平为P<0.05。
■结果表明，纳米颗粒通过破坏和破坏线粒体功能来诱导ROS并减少细胞内谷胱甘肽，通过增加ROS产量，脂质膜的损伤和MDA的增加也很明显。这种作用是剂量依赖性的,并且在25μg/mL的浓度下最大。此外，ZnO纳米颗粒在HT29细胞系中的表现优于在PC3细胞系中的表现。
■这项研究表明，将HT29和PC3癌细胞暴露于不同浓度的氧化锌纳米颗粒通过细胞毒性作用抑制了生长。
