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Abstract：
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with unique binding sites in the 3\'-untranslated region. There is mounting information that suggests RBP dysregulation plays a significant role in carcinogenesis. However, the function of FMR1 autosomal homolog 1(FXR1) in malignancies is just beginning to be unveiled. Due to the diversity of their RNA-binding domains and functional adaptability, FXR1 can regulate diverse transcript processing. Changes in FXR1 interaction with RNA networks have been linked to the emergence of cancer, although the theoretical framework defining these alterations in interaction is insufficient. Alteration in FXR1 expression or localization has been linked to the mRNAs of cancer suppressor genes, cancer-causing genes, and genes involved in genomic expression stability. In particular, FXR1-mediated gene regulation involves in several cellular phenomena related to cancer growth, metastasis, epithelial-mesenchymal transition, senescence, apoptosis, and angiogenesis. FXR1 dysregulation has been implicated in diverse cancer types, suggesting its diagnostic and therapeutic potential. However, the molecular mechanisms and biological effects of FXR1 regulation in cancer have yet to be understood. This review highlights the current knowledge of FXR1 expression and function in various cancer situations, emphasizing its functional variety and complexity. We further address the challenges and opportunities of targeting FXR1 for cancer diagnosis and treatment and propose future directions for FXR1 research in oncology. This work intends to provide an in-depth review of FXR1 as an emerging oncotarget with multiple roles and implications in cancer biology and therapy.
摘要：
RNA结合蛋白(RBP)通过与3'-非翻译区中的独特结合位点的相互作用在转录后调节几种靶RNA(如mRNA)的表达水平。有越来越多的信息表明RBP失调在致癌作用中起着重要作用。然而,FMR1常染色体同源物1(FXR1)在恶性肿瘤中的功能才刚刚开始被揭示.由于其RNA结合域的多样性和功能适应性，FXR1可以调节不同的转录本加工。FXR1与RNA网络相互作用的变化与癌症的出现有关，尽管定义这些相互作用变化的理论框架是不够的。FXR1表达或定位的改变与癌症抑制基因的mRNA有关，致癌基因,和参与基因组表达稳定性的基因。特别是,FXR1介导的基因调控涉及与癌症生长相关的几种细胞现象，转移,上皮-间质转化，衰老，凋亡，和血管生成。FXR1失调与多种癌症类型有关，提示其诊断和治疗潜力。然而,FXR1调控癌症的分子机制和生物学效应还有待了解。这篇综述强调了FXR1在各种癌症情况下的表达和功能的最新知识，强调其功能的多样性和复杂性。我们进一步解决了靶向FXR1用于癌症诊断和治疗的挑战和机遇，并为FXR1在肿瘤学中的研究提出了未来的方向。这项工作旨在提供对FXR1作为一个新兴的共同目标的深入审查，在癌症生物学和治疗中具有多种作用和意义。
