Abstract：
OBJECTIVE: To clarify the clinical, diagnostic, and treatment characteristics of orbital liposarcoma.
METHODS: Retrospective observational case series.
METHODS: A review was performed of electronic medical records, histopathology, radiological images, and follow-up information for 21 patients with orbital liposarcoma.
RESULTS: The predominant clinical manifestation of this disease was painless exophthalmos. The most frequently encountered pathological types were well-differentiated and myxoid liposarcoma. Preoperative radiological images from 15 patients showed that orbital liposarcoma initially developed in extraocular muscle in 9 patients. Furthermore, all well-differentiated liposarcomas exhibited the radiographic characteristics of irregular and ill-defined adipose tissue, whereas only 12.5% of myxoid liposarcomas had the imaging characteristics. For the patients who exclusively underwent surgery, all of those with subtotal excisions experienced recurrence, 63.6% of marginal excisions recurred, and 50% of wide excisions resulted in recurrence. However, none of the patients who underwent marginal excisions or wide excisions combined with adjuvant radiotherapy exhibited recurrence. The analysis of magnetic resonance imaging findings in 3 patients who underwent neoadjuvant radiotherapy revealed that the tumor size remained stable in a patient with well-differentiated liposarcoma, whereas another patient with the same type of tumor exhibited a gradual increase in size. Conversely, a patient with myxoid liposarcoma experienced a significant reduction in tumor size following neoadjuvant radiotherapy.
CONCLUSIONS: Orbital liposarcoma demonstrated a propensity for developing in the extraocular muscle. The radiological images of orbital well-differentiated liposarcomas were characterized by irregular and ill-defined adipose tissue. Surgery combined with radiotherapy demonstrated potential in reducing recurrence rates. Notably, orbital myxoid liposarcoma exhibited greater sensitivity to radiotherapy compared to well-differentiated liposarcoma.
METHODS: Retrospective observational case series.
METHODS: A review was performed of electronic medical records, histopathology, radiological images, and follow-up information for 21 patients with orbital liposarcoma.
RESULTS: The predominant clinical manifestation of this disease was painless exophthalmos. The most frequently encountered pathological types were well-differentiated and myxoid liposarcoma. Preoperative radiological images from 15 patients showed that orbital liposarcoma initially developed in extraocular muscle in 9 patients. Furthermore, all well-differentiated liposarcomas exhibited the radiographic characteristics of irregular and ill-defined adipose tissue, whereas only 12.5% of myxoid liposarcomas had the imaging characteristics. For the patients who exclusively underwent surgery, all of those with subtotal excisions experienced recurrence, 63.6% of marginal excisions recurred, and 50% of wide excisions resulted in recurrence. However, none of the patients who underwent marginal excisions or wide excisions combined with adjuvant radiotherapy exhibited recurrence. The analysis of magnetic resonance imaging findings in 3 patients who underwent neoadjuvant radiotherapy revealed that the tumor size remained stable in a patient with well-differentiated liposarcoma, whereas another patient with the same type of tumor exhibited a gradual increase in size. Conversely, a patient with myxoid liposarcoma experienced a significant reduction in tumor size following neoadjuvant radiotherapy.
CONCLUSIONS: Orbital liposarcoma demonstrated a propensity for developing in the extraocular muscle. The radiological images of orbital well-differentiated liposarcomas were characterized by irregular and ill-defined adipose tissue. Surgery combined with radiotherapy demonstrated potential in reducing recurrence rates. Notably, orbital myxoid liposarcoma exhibited greater sensitivity to radiotherapy compared to well-differentiated liposarcoma.
摘要：
目的：为了阐明临床，眼眶脂肪肉瘤的诊治特点.
方法：回顾性观察病例系列。
方法：电子病历审查，组织病理学,21例眼眶脂肪肉瘤患者的影像学及随访资料。
结果：本病的主要临床表现为无痛性眼球突出。最常见的病理类型是高分化和粘液样脂肪肉瘤。15例患者的术前放射学图像显示，9例患者的眼眶脂肪肉瘤最初在眼外肌中发展。此外，所有分化良好的脂肪肉瘤均表现出不规则和不清晰的脂肪组织的影像学特征，而只有12.5%的黏液样脂肪肉瘤具有影像学特征。对于专门接受手术的患者，所有进行次全切除的病例都经历了复发,63.6％的边缘切除术复发，50％的广泛切除术导致复发。然而,接受边缘切除或广泛切除联合辅助放疗的患者均未出现复发.对3例接受新辅助放疗的患者的MRI表现进行分析，结果显示，分化良好的脂肪肉瘤患者的肿瘤大小保持稳定。而另一位患有相同类型肿瘤的患者表现出大小逐渐增加。相反，1例黏液样脂肪肉瘤患者新辅助放疗后肿瘤大小显著缩小.
结论：眼眶脂肪肉瘤表现出在眼外肌中发展的倾向。分化良好的脂肪肉瘤的放射学图像以不规则和不清晰的脂肪组织为特征。手术联合放疗显示出降低复发率的潜力。值得注意的是,与高分化脂肪肉瘤相比,眼眶黏液样脂肪肉瘤对放疗的敏感性更高.
方法：回顾性观察病例系列。
方法：电子病历审查，组织病理学,21例眼眶脂肪肉瘤患者的影像学及随访资料。
结果：本病的主要临床表现为无痛性眼球突出。最常见的病理类型是高分化和粘液样脂肪肉瘤。15例患者的术前放射学图像显示，9例患者的眼眶脂肪肉瘤最初在眼外肌中发展。此外，所有分化良好的脂肪肉瘤均表现出不规则和不清晰的脂肪组织的影像学特征，而只有12.5%的黏液样脂肪肉瘤具有影像学特征。对于专门接受手术的患者，所有进行次全切除的病例都经历了复发,63.6％的边缘切除术复发，50％的广泛切除术导致复发。然而,接受边缘切除或广泛切除联合辅助放疗的患者均未出现复发.对3例接受新辅助放疗的患者的MRI表现进行分析，结果显示，分化良好的脂肪肉瘤患者的肿瘤大小保持稳定。而另一位患有相同类型肿瘤的患者表现出大小逐渐增加。相反，1例黏液样脂肪肉瘤患者新辅助放疗后肿瘤大小显著缩小.
结论：眼眶脂肪肉瘤表现出在眼外肌中发展的倾向。分化良好的脂肪肉瘤的放射学图像以不规则和不清晰的脂肪组织为特征。手术联合放疗显示出降低复发率的潜力。值得注意的是,与高分化脂肪肉瘤相比,眼眶黏液样脂肪肉瘤对放疗的敏感性更高.
