Abstract：
OBJECTIVE: To compare SF 6 relative with C 2 F 6 in the anatomical and functional outcomes following pars plana vitrectomy for uncomplicated primary pseudophakic rhegmatogenous retinal detachment with inferior causative breaks.
METHODS: This is a retrospective, comparative study on eyes with pseudophakic rhegmatogenous retinal detachment with inferior causative breaks that had small-gauge pars plana vitrectomy repair using SF 6 and C 2 F 6 tamponade between 2011 and 2020 at a tertiary centre in the United Kingdom. Primary outcome was single surgery anatomical success, and the secondary outcome was best-corrected visual acuity. Propensity score matching, using preoperative findings as covariates to account for relevant confounders, was performed.
RESULTS: From 162 pseudophakic rhegmatogenous retinal detachment eyes with inferior causative breaks, the median (interquartile range) follow-up was 82 (52-182) days. The single surgery anatomical success was 156 (96.3%) overall: 47 of 47 (100.0%) and 109 of 115 (94.8%) in the SF 6 and C 2 F 6 groups, respectively ( P = 0.182). Relative to the SF 6 group, the C 2 F 6 group had a higher mean number of tears (SF 6 : 3.1[2.0], C 2 F 6 : 4.5[2.7], P = 0.002) and greater retinal detachment extent (SF 6 : 5.3[2.9], C 2 F 6 : 6.2[2.6] clock hours, P = 0.025). Following propensity score matching analysis, 80 eyes were matched with 40 in each group to homogenize preoperative factors. No significant difference was found in single surgery anatomical success and best-corrected visual acuity between the groups following propensity score matching.
CONCLUSIONS: Primary pars plana vitrectomy with gas tamponade leads to a high single surgery anatomical success rate in uncomplicated pseudophakic rhegmatogenous retinal detachment with inferior causative breaks with no additional benefit associated with long-acting tamponade when comparing C 2 F 6 with SF 6 .
METHODS: This is a retrospective, comparative study on eyes with pseudophakic rhegmatogenous retinal detachment with inferior causative breaks that had small-gauge pars plana vitrectomy repair using SF 6 and C 2 F 6 tamponade between 2011 and 2020 at a tertiary centre in the United Kingdom. Primary outcome was single surgery anatomical success, and the secondary outcome was best-corrected visual acuity. Propensity score matching, using preoperative findings as covariates to account for relevant confounders, was performed.
RESULTS: From 162 pseudophakic rhegmatogenous retinal detachment eyes with inferior causative breaks, the median (interquartile range) follow-up was 82 (52-182) days. The single surgery anatomical success was 156 (96.3%) overall: 47 of 47 (100.0%) and 109 of 115 (94.8%) in the SF 6 and C 2 F 6 groups, respectively ( P = 0.182). Relative to the SF 6 group, the C 2 F 6 group had a higher mean number of tears (SF 6 : 3.1[2.0], C 2 F 6 : 4.5[2.7], P = 0.002) and greater retinal detachment extent (SF 6 : 5.3[2.9], C 2 F 6 : 6.2[2.6] clock hours, P = 0.025). Following propensity score matching analysis, 80 eyes were matched with 40 in each group to homogenize preoperative factors. No significant difference was found in single surgery anatomical success and best-corrected visual acuity between the groups following propensity score matching.
CONCLUSIONS: Primary pars plana vitrectomy with gas tamponade leads to a high single surgery anatomical success rate in uncomplicated pseudophakic rhegmatogenous retinal detachment with inferior causative breaks with no additional benefit associated with long-acting tamponade when comparing C 2 F 6 with SF 6 .
摘要：
目的：比较SF6相对于C2F6在平坦部玻璃体切除术（PPV）治疗无并发症的原发性假性孔源性视网膜脱离（PRD）并伴有下位性断裂后的解剖和功能结果。
方法：这是一个回顾性研究，2011-2020年间,在英国的一个三级中心,对PRD患者进行了使用SF6和C2F6填塞进行小口径PPV修复的劣性致伤眼的对比研究.主要结果是单次手术解剖成功（SSAS）和次要结果，最佳矫正视力（BCVA）。倾向得分匹配(PSM)，使用术前发现作为协变量来解释相关的混杂因素，已执行。
结果：从162个PRD眼睛中，中位(四分位距)随访时间为82(52-182)天.SSAS总体为156（96.3％）；SF6和C2F6组中有47/47（100.0％）和109/115（94.8％），分别(p=0.182)。相对于SF6组，C2F6组的平均眼泪数较高（SF6：3.1[2.0]，C2F6:4.5[2.7],p=0.002）和更大的RD范围（SF6：5.3[2.9]，C2F6:6.2[2.6]小时,p=0.025)。在PSM分析之后，每组80只眼与40只眼匹配，以均质化术前因素。PSM后两组间SSAS和BCVA无显著差异。
结论：将C2F6与SF6进行比较时，在无并发症的PRD中，带有气体填塞的原发性PPV导致较高的SSAS率，具有较差的致病中断，而与长效填塞相关的其他益处没有。
方法：这是一个回顾性研究，2011-2020年间,在英国的一个三级中心,对PRD患者进行了使用SF6和C2F6填塞进行小口径PPV修复的劣性致伤眼的对比研究.主要结果是单次手术解剖成功（SSAS）和次要结果，最佳矫正视力（BCVA）。倾向得分匹配(PSM)，使用术前发现作为协变量来解释相关的混杂因素，已执行。
结果：从162个PRD眼睛中，中位(四分位距)随访时间为82(52-182)天.SSAS总体为156（96.3％）；SF6和C2F6组中有47/47（100.0％）和109/115（94.8％），分别(p=0.182)。相对于SF6组，C2F6组的平均眼泪数较高（SF6：3.1[2.0]，C2F6:4.5[2.7],p=0.002）和更大的RD范围（SF6：5.3[2.9]，C2F6:6.2[2.6]小时,p=0.025)。在PSM分析之后，每组80只眼与40只眼匹配，以均质化术前因素。PSM后两组间SSAS和BCVA无显著差异。
结论：将C2F6与SF6进行比较时，在无并发症的PRD中，带有气体填塞的原发性PPV导致较高的SSAS率，具有较差的致病中断，而与长效填塞相关的其他益处没有。
