Abstract：
OBJECTIVE: This study aims to explore the clinical diagnosis and treatment methods of bladder malakoplakia (MUB) to enhance the understanding of the disease.
METHODS: A retrospective analysis of the diagnosis and treatment processes of three cases of MUB treated in our department was conducted. Relevant literature from both domestic and international sources was reviewed to provide a comprehensive analysis.
RESULTS: All three patients underwent transurethral resection of bladder lesions combined with antibiotic therapy, and two of them received transurethral instillation of gemcitabine. There were two cases with two recurrences each, and one case with four recurrences, with the latter also concurrently presenting with unilateral ureteral malakoplakia. Postoperative pathology confirmed MUB in all three cases. Close follow-up revealed no significant recurrence in the patients.
CONCLUSIONS: The effective diagnosis rate is increased by conducting multiple deep, repetitive, and randomly selected live tissue examinations. The definitive diagnosis of MUB relies on pathological histological examination. Treatment involving a combination of antibiotics and transurethral resection of bladder lesions proves to be effective. Exploring the use of bladder instillation of gemcitabine widens the spectrum of MUB treatment methods.
METHODS: A retrospective analysis of the diagnosis and treatment processes of three cases of MUB treated in our department was conducted. Relevant literature from both domestic and international sources was reviewed to provide a comprehensive analysis.
RESULTS: All three patients underwent transurethral resection of bladder lesions combined with antibiotic therapy, and two of them received transurethral instillation of gemcitabine. There were two cases with two recurrences each, and one case with four recurrences, with the latter also concurrently presenting with unilateral ureteral malakoplakia. Postoperative pathology confirmed MUB in all three cases. Close follow-up revealed no significant recurrence in the patients.
CONCLUSIONS: The effective diagnosis rate is increased by conducting multiple deep, repetitive, and randomly selected live tissue examinations. The definitive diagnosis of MUB relies on pathological histological examination. Treatment involving a combination of antibiotics and transurethral resection of bladder lesions proves to be effective. Exploring the use of bladder instillation of gemcitabine widens the spectrum of MUB treatment methods.
摘要：
目的：本研究旨在探讨膀胱真斑病（MUB）的临床诊断和治疗方法，以提高对该病的认识。
方法：回顾性分析我科收治的3例MUB的诊治过程。回顾了国内外相关文献，以提供全面的分析。
结果：所有3例患者均接受了经尿道膀胱病灶电切术联合抗生素治疗，其中两人接受了吉西他滨的经尿道滴注。有两个病例各有两个复发,一个病例有四次复发，后者也同时出现单侧输尿管硬斑。术后病理均证实MUB。密切随访显示患者无明显复发。
结论：通过进行多个深，重复,并随机选择活组织检查。MUB的明确诊断依赖于病理组织学检查。包括抗生素和经尿道膀胱病变电切术的组合治疗被证明是有效的。探索膀胱滴注吉西他滨的使用拓宽了MUB治疗方法的范围。
方法：回顾性分析我科收治的3例MUB的诊治过程。回顾了国内外相关文献，以提供全面的分析。
结果：所有3例患者均接受了经尿道膀胱病灶电切术联合抗生素治疗，其中两人接受了吉西他滨的经尿道滴注。有两个病例各有两个复发,一个病例有四次复发，后者也同时出现单侧输尿管硬斑。术后病理均证实MUB。密切随访显示患者无明显复发。
结论：通过进行多个深，重复,并随机选择活组织检查。MUB的明确诊断依赖于病理组织学检查。包括抗生素和经尿道膀胱病变电切术的组合治疗被证明是有效的。探索膀胱滴注吉西他滨的使用拓宽了MUB治疗方法的范围。
