Abstract：
Diabetic wound is one of the serious complications of diabetes, and the wound is persistent and easily recurring, which seriously endangers the health and life of patients. How to effectively promote the healing of diabetic wounds has been a hot spot and difficult area of clinical research. Some previous studies have shown that dihydromyricetin has the effects of regulating blood glucose, controlling the severity, and inhibiting scarring. In the present study, we used polylactic-co-glycolic acid nanoparticles as a carrier to load dihydromyricetin to make drug-loaded nanoparticles and applied them dropwise (200 µL) to diabetic mice wounds by topical application to observe the healing and scar formation of diabetic wounds. We found that the healing rate of the diabetic mice was faster and the scar formation was less obvious. In addition, the elevated blood glucose level and weight loss of the mice in the treatment group were also reduced. Therefore, nanoparticle-mediated dihydromyricetin may be an effective treatment for diabetic wounds.
摘要：
糖尿病伤口是糖尿病的严重并发症之一，伤口持久且容易复发，严重危害患者的健康和生命。如何有效促进糖尿病创面的愈合一直是临床研究的热点和难点。以前的一些研究表明，二氢杨梅素有调节血糖的作用，控制严重程度并抑制瘢痕形成。在本研究中,我们以PLGA纳米粒子为载体,负载二氢杨梅素,制成载药纳米粒子,通过局部应用将其逐滴(200µL)应用于糖尿病小鼠创面,观察糖尿病创面的愈合和瘢痕形成.我们发现糖尿病小鼠的愈合速度较快，瘢痕形成不明显。此外,治疗组小鼠的血糖水平升高和体重减轻也降低。因此,纳米颗粒介导的二氢杨梅素可能是糖尿病伤口的有效治疗方法。
