PDF(Pubmed)
Abstract：
OBJECTIVE: The aim of this study was to report clinical observations suggesting the efficacy of topical 1% 5-fluorouracil (5-FU) in treating Demodex -associated blepharitis.
METHODS: An observational retrospective review of 13 eyes from 13 individuals with conjunctival neoplastic lesions and concomitant Demodex lash infestation that received topical 1% 5-FU eye drops. Patients underwent slit-lamp examination at each follow-up visit. Clinical photographs of the lash line were obtained after treatment initiation. In a subset of patients, lashes were epilated bilaterally and microscopically analyzed for presence of Demodex mites before and after treatment initiation.
RESULTS: The mean age of the population was 68 ± 14 years (range: 30-84 years) and 92% were male. In all 13 patients, a marked reduction in cylindrical dandruff was noted in the treated eye by slit-lamp examination after 2 cycles of 5-FU. There was complete resolution of cylindrical dandruff in 10 of 13 treated eyes compared with 0 resolution of cylindrical dandruff in untreated eyes ( P = 0.0001). In the 6 patients who received epilation, the lashes from the treated eye showed no Demodex , whereas lashes from the fellow untreated eye revealed persistent Demodex .
CONCLUSIONS: Topical 1% 5-FU shows efficacy in treating Demodex -associated blepharitis. Further studies are indicated to reproduce our findings and evaluate the potential use of 5-FU as a treatment ingredient.
METHODS: An observational retrospective review of 13 eyes from 13 individuals with conjunctival neoplastic lesions and concomitant Demodex lash infestation that received topical 1% 5-FU eye drops. Patients underwent slit-lamp examination at each follow-up visit. Clinical photographs of the lash line were obtained after treatment initiation. In a subset of patients, lashes were epilated bilaterally and microscopically analyzed for presence of Demodex mites before and after treatment initiation.
RESULTS: The mean age of the population was 68 ± 14 years (range: 30-84 years) and 92% were male. In all 13 patients, a marked reduction in cylindrical dandruff was noted in the treated eye by slit-lamp examination after 2 cycles of 5-FU. There was complete resolution of cylindrical dandruff in 10 of 13 treated eyes compared with 0 resolution of cylindrical dandruff in untreated eyes ( P = 0.0001). In the 6 patients who received epilation, the lashes from the treated eye showed no Demodex , whereas lashes from the fellow untreated eye revealed persistent Demodex .
CONCLUSIONS: Topical 1% 5-FU shows efficacy in treating Demodex -associated blepharitis. Further studies are indicated to reproduce our findings and evaluate the potential use of 5-FU as a treatment ingredient.
摘要：
目的：本研究的目的是报告临床观察结果，提示外用1％5-氟尿嘧啶（5-FU）治疗蠕形螨相关性眼睑炎的疗效。
方法：对13例结膜瘤性病变和伴有蠕形螨睫毛感染的患者的13只眼进行观察性回顾性回顾，这些患者接受了1%5-FU滴眼液。患者在每次随访时接受裂隙灯检查。治疗开始后获得睫毛线的临床照片。在一部分患者中，两侧脱毛睫毛，并在治疗开始之前和之后用显微镜分析蠕形螨的存在。
结果：人群的平均年龄为68±14岁（范围：30-84岁），92％为男性。在所有13名患者中，经过2个周期的5-FU后，通过裂隙灯检查，在治疗的眼睛中发现圆柱形头皮屑明显减少。与未处理的眼睛中的圆柱形头皮屑的0分辨率相比,在13只治疗的眼睛中的10只存在圆柱形头皮屑的完全分辨率(P=0.0001)。在接受脱毛的6名患者中，被治疗眼睛的睫毛显示没有蠕形螨，而未处理的眼睛的睫毛显示出持续的蠕形螨。
结论：外用1%5-FU在治疗蠕形螨相关性眼睑炎方面显示出疗效。进一步的研究表明重现我们的发现，并评估5-FU作为治疗成分的潜在用途。
方法：对13例结膜瘤性病变和伴有蠕形螨睫毛感染的患者的13只眼进行观察性回顾性回顾，这些患者接受了1%5-FU滴眼液。患者在每次随访时接受裂隙灯检查。治疗开始后获得睫毛线的临床照片。在一部分患者中，两侧脱毛睫毛，并在治疗开始之前和之后用显微镜分析蠕形螨的存在。
结果：人群的平均年龄为68±14岁（范围：30-84岁），92％为男性。在所有13名患者中，经过2个周期的5-FU后，通过裂隙灯检查，在治疗的眼睛中发现圆柱形头皮屑明显减少。与未处理的眼睛中的圆柱形头皮屑的0分辨率相比,在13只治疗的眼睛中的10只存在圆柱形头皮屑的完全分辨率(P=0.0001)。在接受脱毛的6名患者中，被治疗眼睛的睫毛显示没有蠕形螨，而未处理的眼睛的睫毛显示出持续的蠕形螨。
结论：外用1%5-FU在治疗蠕形螨相关性眼睑炎方面显示出疗效。进一步的研究表明重现我们的发现，并评估5-FU作为治疗成分的潜在用途。
