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Abstract：
Measles, mumps, and rubella (MMR) are highly infectious viral diseases affecting young children and have high secondary attack rates. Present MMR vaccines show consistent seroconversion rates for anti-measles and anti-rubella antibodies with variable responses for anti-mumps antibodies. Most common strains for MMR vaccines, currently available in India, are the Edmonston-Zagreb measles strain, Leningrad Zagreb (L-Z) mumps strain, and the RA 27/3 rubella strain. L-Z strain of mumps virus has been found to be associated with aseptic meningitis by different studies from different parts of the world including India. Recently, a novel freeze-dried MMR vaccine developed by Zydus Lifesciences (Zyvac MMR) contains Edmonston Zagreb measles strain, Hoshino mumps strain, and RA 27/3 rubella strain. The Hoshino strain is WHO approved and was found to induce interferon gamma production. This review article aims to provide a comprehensive appraisal of the data available on the safety and immunogenicity of the novel MMR vaccine.
摘要：
麻疹,腮腺炎,风疹（MMR）是影响幼儿的高度传染性病毒性疾病，具有很高的二次发作率。目前的MMR疫苗显示出一致的抗麻疹和抗风疹抗体的血清转化率，抗腮腺炎抗体的反应可变。MMR疫苗最常见的菌株，目前在印度可用，是埃德蒙斯顿-萨格勒布麻疹毒株,列宁格勒萨格勒布（L-Z）腮腺炎菌株，和RA27/3风疹菌株。通过来自包括印度在内的世界不同地区的不同研究，发现腮腺炎病毒的L-Z株与无菌性脑膜炎有关。最近,ZydusLifesciences（ZyvacMMR）开发的一种新型冻干MMR疫苗含有埃德蒙斯顿·萨格勒布麻疹毒株，星野腮腺炎菌株，和RA27/3风疹菌株。Hoshino菌株是WHO批准的，并被发现可诱导干扰素γ的产生。本文旨在全面评估有关新型MMR疫苗的安全性和免疫原性的可用数据。
