Abstract：
Swertia species are common ingredients in numerous herbal remedies. It is also used to treat a wide range of illnesses and possess diverse therapeutic activities. The aim of the study is to elucidate the comprehensive metabolomics profile of Swertia chirayita and the role of various extraction methods in the phytochemical compositions of the extracts of S. chirayita, and their antioxidant and enzyme inhibitory activities. Extraction of the stems, leaves, and flowering tops of S. chirayita was performed by maceration, infusion, and soxhlation using methanol and water as solvent. Extracts were subjected to phytochemical profiling by a liquid-chromatographic system. Antioxidant and enzyme inhibitory activity was carried out. The metabolomics profiling showed that a diverse range of specialized metabolites were present in the stems and leaves & flowering tops of the plant. All the extracts showed substantial antioxidant and enzyme inhibitory activities further confirmed by molecular docking studies. This study appraised the use of S. chirayita aerial parts as a potential antioxidant and its therapeutic application in various chronic illnesses including Alzheimer\'s disease, diabetes, and other skin-related disorders.
摘要：
Swertia物种是许多草药中的常见成分。它还用于治疗多种疾病，并具有多种治疗活性。这项研究的目的是阐明Swertiachirayita的全面代谢组学概况以及各种提取方法在S.chirayita提取物的植物化学成分中的作用，以及它们的抗氧化和酶抑制活性。提取茎，叶子,chirayita的开花顶部是通过浸渍进行的，输液,并使用甲醇和水作为溶剂。提取物通过液相色谱系统进行植物化学分析。进行了抗氧化和酶抑制活性。代谢组学分析显示，植物的茎和叶和开花顶部存在各种专门的代谢物。所有提取物均显示出大量的抗氧化和酶抑制活性，并通过分子对接研究进一步证实。这项研究评估了S.chirayita地上部分作为潜在的抗氧化剂的使用及其在各种慢性疾病，包括阿尔茨海默病的治疗应用，糖尿病,和其他皮肤相关疾病。
