Abstract：
OBJECTIVE: The purpose of this study was to find data proving the influence of the Haemophilus influenzae type b (Hib) conjugate vaccination on the frequency of invasive Hib illness.
METHODS: A systematic literature search was conducted on the PubMed database to identify peerreviewed publications pertaining to the epidemiology of Haemophilus influenzae meningitis, both before and after the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines. The search query employed a combination of relevant keywords, including \"invasive,\" \"Haemophilus,\" \"influenzae,\" \"meningitis,\" and specific serotype b (Hib). Additionally, terms related to epidemiology, burden, risk factors, impact, Hib vaccine, Hib conjugate vaccine, combination vaccine, vaccine production, efficacy, immunisation coverage, surveillance, review, clinical aspects, outcomes, and various age groups (adults and children) were incorporated.
RESULTS: The search encompassed articles published till now. Subsequently, relevant research papers concerning Haemophilus influenzae meningitis were subjected to a comprehensive review and analysis.
CONCLUSIONS: The Hib conjugate vaccination has shown to be extremely effective when administered to the entire population. However, changes to the immunisation protocol appear to be required in order to effectively manage invasive Hib illness.
METHODS: A systematic literature search was conducted on the PubMed database to identify peerreviewed publications pertaining to the epidemiology of Haemophilus influenzae meningitis, both before and after the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines. The search query employed a combination of relevant keywords, including \"invasive,\" \"Haemophilus,\" \"influenzae,\" \"meningitis,\" and specific serotype b (Hib). Additionally, terms related to epidemiology, burden, risk factors, impact, Hib vaccine, Hib conjugate vaccine, combination vaccine, vaccine production, efficacy, immunisation coverage, surveillance, review, clinical aspects, outcomes, and various age groups (adults and children) were incorporated.
RESULTS: The search encompassed articles published till now. Subsequently, relevant research papers concerning Haemophilus influenzae meningitis were subjected to a comprehensive review and analysis.
CONCLUSIONS: The Hib conjugate vaccination has shown to be extremely effective when administered to the entire population. However, changes to the immunisation protocol appear to be required in order to effectively manage invasive Hib illness.
摘要：
目的：本研究的目的是寻找证明b型流感嗜血杆菌（Hib）结合疫苗接种对侵袭性Hib疾病频率的影响的数据。
方法：在PubMed数据库上进行了系统的文献检索，以确定与流感嗜血杆菌脑膜炎流行病学有关的同行审查的出版物，在引入b型流感嗜血杆菌（Hib）结合疫苗之前和之后。搜索查询采用了相关关键字的组合，包括“侵入性”，\"\"嗜血杆菌,\"\"流感,脑膜炎,“和特定血清型b（Hib）。此外,与流行病学相关的术语，负担，危险因素，影响，Hib疫苗,Hib结合疫苗，联合疫苗，疫苗生产,功效,免疫覆盖率，监视,review,临床方面，结果，并纳入了不同年龄组(成人和儿童)。
结果：搜索内容包含到现在为止发表的文章。随后，对流感嗜血杆菌性脑膜炎的相关研究论文进行全面回顾和分析。
结论:当给予整个群体时,Hib缀合物接种已显示出极其有效。然而,为了有效管理侵入性Hib疾病，似乎需要改变免疫方案。
方法：在PubMed数据库上进行了系统的文献检索，以确定与流感嗜血杆菌脑膜炎流行病学有关的同行审查的出版物，在引入b型流感嗜血杆菌（Hib）结合疫苗之前和之后。搜索查询采用了相关关键字的组合，包括“侵入性”，\"\"嗜血杆菌,\"\"流感,脑膜炎,“和特定血清型b（Hib）。此外,与流行病学相关的术语，负担，危险因素，影响，Hib疫苗,Hib结合疫苗，联合疫苗，疫苗生产,功效,免疫覆盖率，监视,review,临床方面，结果，并纳入了不同年龄组(成人和儿童)。
结果：搜索内容包含到现在为止发表的文章。随后，对流感嗜血杆菌性脑膜炎的相关研究论文进行全面回顾和分析。
结论:当给予整个群体时,Hib缀合物接种已显示出极其有效。然而,为了有效管理侵入性Hib疾病，似乎需要改变免疫方案。
