Abstract：
Introduction: In this systematic review the topical hemostatic properties of Cyanoacrylate Adhesives (CA) have been studied.
Material and Method: Four major scientific databases (Embase, Scopus, PubMed, and Web of Science) were inquired, retrieving reviews and meta-analysis studies, clinical trials, experimental studies, and case reports that presented data regarding topical hemostasis and CA. English written articles, published in the last 10 years were collected. The last search was performed on the 1st of August 2023. Risk of bias in the included studies was assessed using study-design specific, evidence-based tools.
Results: A summary focused on relevant information of all included studies was drafted and the results of the studies have been synthetized and compared. A total of 42 studies have been included in the review (14 reviews and meta-analysis, 11 clinical trials, 9 experimental studies and 8 case reports). CA exhibited important topical hemostatic capabilities, comparable with other performant hemostatic materials. Although most included studies concluded that CA were potent topical hemostatic agents, the high level of heterogeneity among the studies prevented us from performing a meta-analysis.
Conclusion: The results of this review show that CA-based compounds represent an important line of research towards the perfect hemostatic material.
摘要：
简介：在这篇系统综述中，研究了氰基丙烯酸酯粘合剂（CA）的局部止血性能。材料与方法：四大科学数据库(Embase，Scopus,PubMed,和WebofScience)被询问，检索评论和荟萃分析研究，临床试验,实验研究,以及提供有关局部止血和CA数据的病例报告。英文书面文章,收集了最近10年出版的。最后一次搜索是在2023年8月1日进行的。纳入研究的偏倚风险是使用研究设计特异性评估的，基于证据的工具。结果：对所有纳入研究的相关信息进行了总结，并对研究结果进行了综合和比较。共有42项研究被纳入综述(14项综述和荟萃分析，11项临床试验,9项实验研究和8例病例报告)。CA表现出重要的局部止血能力，与其他高性能止血材料相当。尽管大多数纳入研究的结论是CA是有效的局部止血剂，研究中的高度异质性阻碍了我们进行荟萃分析.结论：本综述的结果表明，基于CA的化合物代表了完美止血材料的重要研究方向。
