Abstract：
OBJECTIVE: A consensus has not been reached on the value of quality of life (QoL) as a prognostic factor for survival in gastrointestinal cancer. This meta-analysis aimed to investigate the association between functioning scales of the EORTC QoL Questionnaire Core 30 (QLQ-C30) and the overall survival (OS) in patients with gastrointestinal cancer.
METHODS: A systematic literature search was conducted in PubMed, Web of Science, and Embase databases, until February 7, 2023. The studies included were those that investigated the association between baseline QoL measured by the functioning scales of EORTC QLQ-C30 and OS in patients with gastrointestinal cancer. The prognostic capacity of QoL was calculated by pooling the adjusted hazard ratios (HR) with 95% confidence intervals (CI).
RESULTS: Twenty-four studies\' analyses reported by 22 eligible articles involving 11,609 patients were included. When compared with good parameters of QoL, poor global QoL (HR 1.81; 95% CI 1.53-2.13), physical functioning (HR 1.51; 95% CI 1.31-1.74), social functioning (HR 1.67; 95% CI 1.30-2.15), and role functioning scale (HR 1.42; 95% CI 1.20-1.29) were significantly associated with decreased OS. For each 10-point increase in QLQ-C30 parameters, the pooled HR of OS was 0.87 (95% CI 0.83-0.92) for global QoL, 0.87 (95% CI 0.83-0.92) for physical functioning, and 0.93 (95% CI 0.88-0.97) for role functioning. However, each 10-point increase in social, emotional, or cognitive functioning scale did not significantly predict OS.
CONCLUSIONS: Baseline health-related QoL defined by the physical functioning or global QoL scale of EORTC QLQ-C30 significantly predicts OS in patients with gastrointestinal cancer.
METHODS: A systematic literature search was conducted in PubMed, Web of Science, and Embase databases, until February 7, 2023. The studies included were those that investigated the association between baseline QoL measured by the functioning scales of EORTC QLQ-C30 and OS in patients with gastrointestinal cancer. The prognostic capacity of QoL was calculated by pooling the adjusted hazard ratios (HR) with 95% confidence intervals (CI).
RESULTS: Twenty-four studies\' analyses reported by 22 eligible articles involving 11,609 patients were included. When compared with good parameters of QoL, poor global QoL (HR 1.81; 95% CI 1.53-2.13), physical functioning (HR 1.51; 95% CI 1.31-1.74), social functioning (HR 1.67; 95% CI 1.30-2.15), and role functioning scale (HR 1.42; 95% CI 1.20-1.29) were significantly associated with decreased OS. For each 10-point increase in QLQ-C30 parameters, the pooled HR of OS was 0.87 (95% CI 0.83-0.92) for global QoL, 0.87 (95% CI 0.83-0.92) for physical functioning, and 0.93 (95% CI 0.88-0.97) for role functioning. However, each 10-point increase in social, emotional, or cognitive functioning scale did not significantly predict OS.
CONCLUSIONS: Baseline health-related QoL defined by the physical functioning or global QoL scale of EORTC QLQ-C30 significantly predicts OS in patients with gastrointestinal cancer.
摘要：
目的：关于生活质量（QoL）作为胃肠道肿瘤生存预后因素的价值尚未达成共识。这项荟萃分析旨在调查EORTCQoL问卷核心30（QLQ-C30）的功能量表与胃肠道癌症患者的总生存期（OS）之间的关系。
方法：在PubMed，WebofScience,和Embase数据库，直到2023年2月7日。这些研究包括那些通过EORTCQLQ-C30的功能量表测量的基线QoL与胃肠道癌症患者的OS之间的关联。通过合并调整后的风险比（HR）和95％置信区间（CI）来计算QoL的预后能力。
结果：纳入了22篇合格文章报道的24项研究分析，涉及11,609名患者。与良好的QoL参数相比，全球生活质量差（HR1.81；95%CI1.53-2.13），身体功能（HR1.51；95%CI1.31-1.74），社会功能（HR1.67；95%CI1.30-2.15），和角色功能量表（HR1.42；95％CI1.20-1.29）与OS降低显着相关。对于QLQ-C30参数每增加10点，全球QoL的OS汇总HR为0.87（95%CI0.83-0.92），身体功能为0.87（95%CI0.83-0.92），角色功能为0.93（95%CI0.88-0.97）。然而,社会每增加10个百分点，情感,或认知功能量表对OS无显著预测。
结论：由EORTCQLQ-C30的身体功能或整体QoL量表定义的基线健康相关QoL可显著预测胃肠道肿瘤患者的OS。
方法：在PubMed，WebofScience,和Embase数据库，直到2023年2月7日。这些研究包括那些通过EORTCQLQ-C30的功能量表测量的基线QoL与胃肠道癌症患者的OS之间的关联。通过合并调整后的风险比（HR）和95％置信区间（CI）来计算QoL的预后能力。
结果：纳入了22篇合格文章报道的24项研究分析，涉及11,609名患者。与良好的QoL参数相比，全球生活质量差（HR1.81；95%CI1.53-2.13），身体功能（HR1.51；95%CI1.31-1.74），社会功能（HR1.67；95%CI1.30-2.15），和角色功能量表（HR1.42；95％CI1.20-1.29）与OS降低显着相关。对于QLQ-C30参数每增加10点，全球QoL的OS汇总HR为0.87（95%CI0.83-0.92），身体功能为0.87（95%CI0.83-0.92），角色功能为0.93（95%CI0.88-0.97）。然而,社会每增加10个百分点，情感,或认知功能量表对OS无显著预测。
结论：由EORTCQLQ-C30的身体功能或整体QoL量表定义的基线健康相关QoL可显著预测胃肠道肿瘤患者的OS。
