PDF(Pubmed)
Abstract：
Epithelial tumors with neuroendocrine and nonendocrine components constitute the rare yet aggressive entity of neoplasms of the gastro-entero-pancreatic tract. These tumors were first named \"mixed adeno-neuroendocrine carcinomas\" (MANECs) by the World Health Organization in 2010 and in 2017 renamed \"mixed neuroendocrine non-neuroendocrine neoplasms\" (MiNENs). Combined adenocarcinoma and neuroendocrine carcinoma neoplasms are a rare occurrence within the gastrointestinal tract. In this report, we describe two separate cases of mixed rectal adeno-neuroendocrine carcinomas and their treatment. We describe two cases at one institution of mixed neuroendocrine non-neuroendocrine rectal neoplasms. Given the rarity of diagnosis and inconsistencies in both nomenclature and treatment recommendations in the literature, mixed adeno-neuroendocrine carcinoma epidemiology and prognosis are not yet fully understood. Future prospective trials with a focus in management of MiNENs will offer valuable insight into these rare mixed carcinomas.
摘要：
具有神经内分泌和非内分泌成分的上皮性肿瘤构成了胃肠道胰腺肿瘤的罕见但侵袭性实体。这些肿瘤于2010年被世界卫生组织首次命名为“混合性腺神经内分泌癌”（MANECs），并于2017年更名为“混合性神经内分泌非神经内分泌肿瘤”（MINENs）。合并的腺癌和神经内分泌癌肿瘤在胃肠道内很少发生。在这份报告中,我们描述了两例直肠混合性腺神经内分泌癌及其治疗。我们描述了一个混合性神经内分泌非神经内分泌直肠肿瘤的两个病例。鉴于文献中的罕见诊断和术语和治疗建议的不一致，混合性腺神经内分泌癌的流行病学和预后尚未完全了解.未来以MiNENs管理为重点的前瞻性试验将为这些罕见的混合癌提供有价值的见解。
