{Reference Type}: Case Reports
{Title}: Mixed Adeno-Neuroendocrine Neoplasms: Two Cases, One Institution.
{Author}: Paterson C;Perrotti G;Mushtaq B;Heilman J;Fassler S;
{Journal}: CRSLS
{Volume}: 10
{Issue}: 4
{Year}: 2023 Oct-Dec
暂无{DOI}: 10.4293/CRSLS.2023.00045
{Abstract}: Epithelial tumors with neuroendocrine and nonendocrine components constitute the rare yet aggressive entity of neoplasms of the gastro-entero-pancreatic tract. These tumors were first named "mixed adeno-neuroendocrine carcinomas" (MANECs) by the World Health Organization in 2010 and in 2017 renamed "mixed neuroendocrine non-neuroendocrine neoplasms" (MiNENs). Combined adenocarcinoma and neuroendocrine carcinoma neoplasms are a rare occurrence within the gastrointestinal tract. In this report, we describe two separate cases of mixed rectal adeno-neuroendocrine carcinomas and their treatment. We describe two cases at one institution of mixed neuroendocrine non-neuroendocrine rectal neoplasms. Given the rarity of diagnosis and inconsistencies in both nomenclature and treatment recommendations in the literature, mixed adeno-neuroendocrine carcinoma epidemiology and prognosis are not yet fully understood. Future prospective trials with a focus in management of MiNENs will offer valuable insight into these rare mixed carcinomas.