PDF(Pubmed)
Abstract：
Chronic liver illnesses pose a substantial worldwide health challenge, with various causes that span from viral infections to metabolic problems. Individuals suffering from liver problems frequently face distinct difficulties in pain control, requiring a customized strategy that takes into account both the fundamental disease and the complexities of liver function. The liver, a vital organ responsible for metabolic control and detoxification, is pivotal in multiple physiological processes. Chronic liver illnesses, such as cirrhosis and non-alcoholic fatty liver disease (NAFLD), are marked by a gradual process of inflammation and fibrosis, resulting in reduced liver function. These disorders often come with pain, varying from internal discomfort to intense abdominal pain, which impacts the quality of life and general well-being of patients. The review explores the complex aspects of pain perception in liver illnesses, including inflammation, modified neuronal signaling, and the influence of comorbidities. It highlights the significance of a detailed comprehension of the pain experience in individuals with hepatic conditions for the implementation of successful pain management treatments. In addition, the review emphasizes the difficulties involved in treating pain in this group of patients, such as the possible complications linked to commonly prescribed pain relievers and the necessity for collaboration between hepatologists, pain specialists, and other healthcare professionals. Moreover, it examines new possibilities in the domain, such as the significance of innovative pharmacological substances, non-pharmacological treatments, and personalized medicine strategies designed for specific patient characteristics. This study thoroughly analyzes the difficulties and possibilities involved in creating personalized pain management approaches for individuals with liver conditions. Its purpose is to guide physicians, researchers, and healthcare providers, enabling them to implement more efficient and patient-focused interventions. As our comprehension of liver-related pain progresses, the potential for enhancing the quality of life for persons with chronic liver disorders through tailored pain management measures becomes more and more encouraging.
摘要：
慢性肝病对全球健康构成重大挑战从病毒感染到代谢问题的各种原因。患有肝脏问题的人经常在疼痛控制方面面临明显的困难，需要一个定制的策略，同时考虑到基础疾病和肝功能的复杂性。肝脏，负责代谢控制和排毒的重要器官，在多个生理过程中至关重要。慢性肝病,如肝硬化和非酒精性脂肪性肝病（NAFLD），以炎症和纤维化的渐进过程为标志，导致肝功能下降。这些疾病通常伴随着疼痛，从内部不适到剧烈的腹痛，影响患者的生活质量和总体福祉。这篇综述探讨了肝病中疼痛感知的复杂方面，包括炎症,修饰的神经元信号，以及合并症的影响。它强调了详细了解肝病患者的疼痛经历对于实施成功的疼痛管理治疗的重要性。此外,该综述强调了该组患者治疗疼痛的困难，例如与常用止痛药相关的可能并发症，以及肝病学家之间合作的必要性，疼痛专家,和其他医疗保健专业人员。此外，它研究了该领域的新可能性，例如创新药理物质的意义，非药物治疗,和针对特定患者特征设计的个性化医疗策略。这项研究彻底分析了为肝病患者创建个性化疼痛管理方法所涉及的困难和可能性。它的目的是指导医生，研究人员,和医疗保健提供者，使他们能够实施更有效和以患者为中心的干预措施。随着我们对肝脏相关疼痛的理解的进展，通过量身定制的疼痛管理措施提高慢性肝病患者生活质量的潜力越来越令人鼓舞.
