PDF(Pubmed)
Abstract：
UNASSIGNED: Insufficient sleep is linked to several health problems. Previous studies on the effects of sleep deprivation on cortical excitability using conventional transcranial magnetic stimulation (TMS) included a limited number of modalities, and few inter-stimulus intervals (ISIs) and showed conflicting results. This study aimed to investigate the effects of sleep deprivation on cortical excitability through threshold-tracking TMS, using a wide range of protocols at multiple ISIs.
UNASSIGNED: Fifteen healthy subjects (mean age ± SD: 36 ± 3.34 years) were included. The following tests were performed before and after 24 h of sleep deprivation using semi-automated threshold-tacking TMS protocols: short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) at 11 ISIs between 1 and 30 ms, short interval intracortical facilitation (SICF) at 14 ISIs between 1 and 4.9 ms, long interval intracortical inhibition (LICI) at 6 ISIs between 50 and 300 ms, and short-latency afferent inhibition (SAI) at 12 ISIs between 16 and 30 ms.
UNASSIGNED: No significant differences were observed between pre- and post-sleep deprivation measurements for SICI, ICF, SICF, or LICI at any ISIs (p < 0.05). As for SAI, we found a difference at 28 ms (p = 0.007) and 30 ms (p = 0.04) but not at other ISIs.
UNASSIGNED: Sleep deprivation does not affect cortical excitability except for SAI.
UNASSIGNED: This study confirms some of the previous studies while contradicting others.
UNASSIGNED: Fifteen healthy subjects (mean age ± SD: 36 ± 3.34 years) were included. The following tests were performed before and after 24 h of sleep deprivation using semi-automated threshold-tacking TMS protocols: short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) at 11 ISIs between 1 and 30 ms, short interval intracortical facilitation (SICF) at 14 ISIs between 1 and 4.9 ms, long interval intracortical inhibition (LICI) at 6 ISIs between 50 and 300 ms, and short-latency afferent inhibition (SAI) at 12 ISIs between 16 and 30 ms.
UNASSIGNED: No significant differences were observed between pre- and post-sleep deprivation measurements for SICI, ICF, SICF, or LICI at any ISIs (p < 0.05). As for SAI, we found a difference at 28 ms (p = 0.007) and 30 ms (p = 0.04) but not at other ISIs.
UNASSIGNED: Sleep deprivation does not affect cortical excitability except for SAI.
UNASSIGNED: This study confirms some of the previous studies while contradicting others.
摘要：
■睡眠不足与几个健康问题有关。先前使用常规经颅磁刺激（TMS）对睡眠剥夺对皮质兴奋性的影响的研究包括有限数量的模式，很少有刺激间隔(ISI)，并显示出相互矛盾的结果。本研究旨在通过阈值追踪TMS研究睡眠剥夺对皮质兴奋性的影响,在多个ISI上使用广泛的协议。
■包括15名健康受试者（平均年龄±SD：36±3.34岁）。在睡眠剥夺24小时之前和之后，使用半自动阈值跟踪TMS协议进行了以下测试：在1到30ms之间的11个ISI时，短间隔皮质内抑制（SICI）和皮质内促进（ICF），在1到4.9ms之间的14个ISI处的短间隔皮质内促进(SICF)，在50到300ms之间的6个ISI时的长间隔皮质内抑制（LICI），以及在16和30ms之间的12个ISI处的短潜伏期传入抑制(SAI)。
■在SICI、ICF、SICF,或LICI在任何ISI(p<0.05)。至于SAI,我们发现在28ms（p=0.007）和30ms（p=0.04）之间存在差异，但在其他ISI处没有差异。
■除SAI外，睡眠剥夺不影响皮质兴奋性。
■这项研究证实了以前的一些研究，但与其他研究相矛盾。
■包括15名健康受试者（平均年龄±SD：36±3.34岁）。在睡眠剥夺24小时之前和之后，使用半自动阈值跟踪TMS协议进行了以下测试：在1到30ms之间的11个ISI时，短间隔皮质内抑制（SICI）和皮质内促进（ICF），在1到4.9ms之间的14个ISI处的短间隔皮质内促进(SICF)，在50到300ms之间的6个ISI时的长间隔皮质内抑制（LICI），以及在16和30ms之间的12个ISI处的短潜伏期传入抑制(SAI)。
■在SICI、ICF、SICF,或LICI在任何ISI(p<0.05)。至于SAI,我们发现在28ms（p=0.007）和30ms（p=0.04）之间存在差异，但在其他ISI处没有差异。
■除SAI外，睡眠剥夺不影响皮质兴奋性。
■这项研究证实了以前的一些研究，但与其他研究相矛盾。
