PDF(Pubmed)
Abstract：
This case report reports the effects of an 18-week physiotherapy program in children with mitochondrial membrane protein-associated neurodegeneration (MPAN). The study involved two brothers, aged 11 and 12, who had been diagnosed with MPAN. The physiotherapy program was divided into three phases and consisted of 18 weeks of training with a pediatric physiotherapist, including balance, coordination, and strengthening exercises. Muscle strength was assessed using pediatric manual muscle testing, functional balance using the Pediatric Berg Balance Test (PBBT), static balance using the Single-Leg Stance Test, dynamic balance using the Functional Reach Test, postural control using the 5-Time Sit-to-Stand Test, and independence using the Functional Independence Measure for Children (WeeFIM). Positive changes were observed in muscle strength, balance, and independence. After Phase I, PBBT scores (younger sibling +4, 8.1%; older +3, 6.8%) were higher than the minimal clinically important difference (MCID=3.66-5.83). After Phase III, although the PBBT scores improved (younger +2, 4.05%; older +1, 2.3%), the older sibling\'s score was not higher than the MCID. Thus, the two children showed visible improvements in both body structure and function, as well as activity and participation levels.
摘要：
该病例报告报告了18周的物理治疗计划对线粒体膜蛋白相关神经变性（MPAN）儿童的影响。这项研究涉及两个兄弟，11岁和12岁，被诊断患有MPAN。物理治疗计划分为三个阶段，包括与儿科物理治疗师进行18周的培训，包括平衡，协调,加强锻炼。使用小儿手动肌肉测试评估肌肉力量，使用儿科伯格平衡测试（PBBT）的功能平衡，使用单腿姿态测试的静态平衡，使用功能达到测试的动态平衡,使用5次坐姿测试的姿势控制，和独立性使用儿童功能独立性测量(WeeFIM)。观察到肌肉力量的积极变化，balance,和独立。第一阶段之后,PBBT评分（较年轻的兄弟姐妹+4，8.1%；较大的+3，6.8%）高于最小的临床重要差异（MCID=3.66-5.83）。第三阶段之后,虽然PBBT得分有所改善(年轻+2，4.05%；年长+1，2.3%)，年长的兄弟姐妹的分数不高于MCID。因此，这两个孩子的身体结构和功能都有明显的改善，以及活动和参与水平。
