METHODS: Healthy White European and South Asian participants in the UK Biobank Imaging CMR sub-study were identified by excluding those with a history of cardiovascular disease, hypertension, obesity or diabetes. Ethnic groups were matched by age and sex. Cardiac volumes, mass and feature tracking strain were compared.
RESULTS: 121 matched pairs (77 male/44 female, mean age 58 ± 8 years) of South Asian and White European participants were included. South Asian males and females had smaller absolute but not indexed left ventricular (LV) volumes, and smaller absolute and indexed right ventricular volumes, with lower absolute and indexed LV mass and lower LV mass:volume than White European participants. Although there were no differences in ventricular or atrial ejection fractions, LV global longitudinal strain was higher in South Asian females than White European females but not males, and global circumferential strain was higher in both male and South Asian females than White European females. Peak early diastolic strain rates were higher in South Asian versus White European males, but not different between South Asian and White European females.
CONCLUSIONS: Contrary to echocardiographic studies, South Asian participants in the UK Biobank study had less concentric remodelling and higher global circumferential strain than White European subjects. These findings emphasise the importance of sex- and ethnic- specific normal ranges for cardiac volumes and function.
方法:英国生物库成像CMR子研究中的健康白人欧洲和南亚参与者通过排除有心血管疾病史的人进行鉴定,高血压,肥胖或糖尿病。种族按年龄和性别匹配。心脏容量,质量和特征跟踪应变进行了比较。
结果:121对匹配(77男/44女,包括平均年龄58±8岁)的南亚和欧洲白人参与者。南亚男性和女性的左心室(LV)绝对容积较小,但没有指数,和较小的绝对和指数右心室容积,与欧洲白人参与者相比,具有较低的绝对和指数LV质量和较低的LV质量:体积。尽管心室或心房射血分数没有差异,南亚女性的LV全球纵向应变高于欧洲白人女性,而不是男性,男性和南亚女性的全球圆周应变均高于欧洲白人女性。南亚男性与欧洲白人男性的早期舒张应变率峰值较高,但南亚和欧洲白人女性没有什么不同。
结论:与超声心动图研究相反,与欧洲白人受试者相比,英国生物银行研究的南亚参与者的同心重塑较少,全球圆周应变较高。这些发现强调了性别和种族特异性正常范围对心脏容积和功能的重要性。