Abstract：
Aspirin-exacerbated respiratory disease (AERD) is a syndrome of high type 2 inflammation and is known to critically involve mast cell activation. The mast cell is an important cell in the baseline inflammatory processes in the upper and lower airway by maintaining and amplifying type 2 inflammation. But it also is prominent in the hypersensitivity reaction to COX-1 inhibition which defines this condition.
Recent work highlights the mast cell as a focal point in AERD pathogenesis. Using AERD as a specific model of both high type 2 asthma and chronic sinusitis, the role of mast cell activity can be better understood in other aspects of airway inflammation. Further dissecting out the mechanism of COX-1-mediated mast cell activation in AERD will be an important next phase in our understanding of NSAID-induced hypersensitivity as well as AERD pathophysiology.
Recent work highlights the mast cell as a focal point in AERD pathogenesis. Using AERD as a specific model of both high type 2 asthma and chronic sinusitis, the role of mast cell activity can be better understood in other aspects of airway inflammation. Further dissecting out the mechanism of COX-1-mediated mast cell activation in AERD will be an important next phase in our understanding of NSAID-induced hypersensitivity as well as AERD pathophysiology.
摘要：
目的：阿司匹林加剧的呼吸系统疾病（AERD）是一种2型高炎症综合征，已知与肥大细胞活化密切相关。通过维持和放大2型炎症,肥大细胞是上、下气道基线炎症过程中的重要细胞。但它在定义这种情况的COX-1抑制的超敏反应中也很突出。
结果：最近的工作强调肥大细胞是AERD发病机制的焦点。使用AERD作为高2型哮喘和慢性鼻窦炎的特定模型，在气道炎症的其他方面可以更好地理解肥大细胞活性的作用。进一步剖析COX-1介导的肥大细胞活化在AERD中的机制将是我们理解NSAID诱导的超敏反应以及AERD病理生理学的重要下一阶段。
结果：最近的工作强调肥大细胞是AERD发病机制的焦点。使用AERD作为高2型哮喘和慢性鼻窦炎的特定模型，在气道炎症的其他方面可以更好地理解肥大细胞活性的作用。进一步剖析COX-1介导的肥大细胞活化在AERD中的机制将是我们理解NSAID诱导的超敏反应以及AERD病理生理学的重要下一阶段。
