Abstract：
A circular shunt is a poor prognostic factor associated with Ebstein\'s anomaly. Targeting the constriction of the ductus arteriosus (DA) in order to limit or resolve the circular shunt, has been shown to improve fetal outcomes. Prenatal non-steroidal anti-inflammatory drugs (NSAIDs) have been known to constrict the DA. Recently, prenatal NSAIDs have been used for that purpose in the treatment of circular shunt. Limited research shows that it may be an effective treatment leading to improved fetal outcomes. In this article, we did an extensive review of literature to describe this therapy\'s effectiveness and outcomes. 82% of fetuses were able to achieve ductal constriction with prenatal NSAID therapy. For fetuses who achieved ductal constriction, fetal demise was less likely (6%) when compared to those who were unable to achieve the same (50%). Of all the fetuses with hydrops, 50% had resoluation of hydrops with prenatal NSAID treatment.
摘要：
圆形分流是与Ebstein异常相关的不良预后因素。针对动脉导管（DA）的收缩，以限制或解决圆形分流，已被证明可以改善胎儿结局。已知产前非甾体抗炎药（NSAID）会限制DA。最近,产前NSAIDs已用于治疗圆形分流术。有限的研究表明，它可能是改善胎儿结局的有效治疗方法。在这篇文章中,我们对该疗法的有效性和结局进行了大量文献综述.82％的胎儿能够通过产前NSAID治疗实现导管狭窄。对于实现导管收缩的胎儿，胎儿死亡的可能性较小(6%),而那些无法达到同样水平的人(50%).在所有有积水的胎儿中，50％的人在产前NSAID治疗后缓解了水肿。
