OBJECTIVE: The aim of this study was to evaluate the efficacy of the combined intrathecal baclofen infusion (ITB) - botulinum toxin treatment in the management of spasticity in CP.
METHODS: 8 patients with spastic tetraparesis were enrolled. All patients were treated with intrathecal Baclofen; in lower limbs, no spastic symptoms appeared, while marked spasticity was noted in upper limbs. We injected the right and left Biceps Brachial (BB) and Flexor Digitorum Superficialis (FDS) muscles with botulinum toxin type A. All patients underwent Myometric measurement, Ashworth Scale, Numerical Rating Scale, and Visual Analogic Scale evaluation before infiltration (T0), 30 days after injection (T1), 60 days after injection (T2), and 90 days after treatment (T3).
RESULTS: All data demonstrated an improvement in spasticity, pain, quality of life, and self-care during the study, with p < 0.05. No side effects appeared.
CONCLUSIONS: This study demonstrated the efficacy and safety of intrathecal baclofen infusion and botulinum toxin combined treatment in the management of spasticity, pain, quality of life, and selfcare in CP patients.
目的:本研究的目的是评估鞘内注射巴氯芬(ITB)-肉毒杆菌毒素联合治疗对CP痉挛的疗效。
方法:8例痉挛性四瘫患者。所有患者均鞘内注射巴氯芬;在下肢,没有出现痉挛症状,而上肢明显痉挛。我们向左右肱二头肌(BB)和下腰屈肌(FDS)肌肉注射A型肉毒杆菌毒素。AshworthScale,数值评级量表,和渗透前视觉类比量表评估(T0),注射后30天(T1),注射后60天(T2),治疗后90天(T3)。
结果:所有数据显示痉挛改善,疼痛,生活质量,在研究过程中自我照顾,p<0.05。没有出现副作用。
结论:这项研究证明了鞘内注射巴氯芬和肉毒杆菌毒素联合治疗痉挛的有效性和安全性,疼痛,生活质量,CP患者的自我护理。