Abstract：
BACKGROUND: Common hyperkeratotic palmar skin lesions include chronic hand eczema (CHE), hyperkeratotic hand eczema (HHE), palmar psoriasis (PP). However, clinically differentiating these disorders is often challenging.
OBJECTIVE: To compare the expressions of keratin (K) 5, K9, K14 and involucrin in palmar hyperkeratotic lesions (HHE, CHE and PP).
METHODS: Immunohistochemical staining was performed on skin biopsy specimens obtained from the palms of patients clinically diagnosed with CHE, HHE and PP (n = 21, 24 and 18, respectively).
RESULTS: K5 and K14 expression levels were higher in the spinous and granular layers of PP and HHE compared to CHE. Involucrin was expressed in the basal layer of PP and HHE but not in CHE. K9 expression was decreased in PP and HHE compared to CHE.
CONCLUSIONS: Keratin and involucrin expression in the epidermis are markers of keratinocyte differentiation. Expression levels of keratin and involucrin were similar between the HHE and PP groups, suggesting that HHE shares pathogenesis with PP rather than CHE.
OBJECTIVE: To compare the expressions of keratin (K) 5, K9, K14 and involucrin in palmar hyperkeratotic lesions (HHE, CHE and PP).
METHODS: Immunohistochemical staining was performed on skin biopsy specimens obtained from the palms of patients clinically diagnosed with CHE, HHE and PP (n = 21, 24 and 18, respectively).
RESULTS: K5 and K14 expression levels were higher in the spinous and granular layers of PP and HHE compared to CHE. Involucrin was expressed in the basal layer of PP and HHE but not in CHE. K9 expression was decreased in PP and HHE compared to CHE.
CONCLUSIONS: Keratin and involucrin expression in the epidermis are markers of keratinocyte differentiation. Expression levels of keratin and involucrin were similar between the HHE and PP groups, suggesting that HHE shares pathogenesis with PP rather than CHE.
摘要：
背景：常见的过度角化手掌皮肤病变包括慢性手部湿疹（CHE），过度角化手部湿疹（HHE），手掌型银屑病（PP）。然而,临床上区分这些疾病通常具有挑战性。
目的：比较手掌角化过度病变中角蛋白（K）5，K9，K14和总蛋白的表达（HHE，CHE和PP）。
方法：对从临床诊断为CHE的患者的手掌获得的皮肤活检标本进行免疫组织化学染色，HHE和PP(分别为n=21、24和18)。
结果：与CHE相比，PP和HHE的棘突层和颗粒层中的K5和K14表达水平更高。总合蛋白在PP和HHE的基底层中表达，但在CHE中不表达。与CHE相比,PP和HHE中的K9表达降低。
结论：表皮中角蛋白和总蛋白的表达是角质形成细胞分化的标志。HHE组和PP组之间角蛋白和总蛋白的表达水平相似，这表明HHE与PP而不是CHE具有共同的发病机制。
目的：比较手掌角化过度病变中角蛋白（K）5，K9，K14和总蛋白的表达（HHE，CHE和PP）。
方法：对从临床诊断为CHE的患者的手掌获得的皮肤活检标本进行免疫组织化学染色，HHE和PP(分别为n=21、24和18)。
结果：与CHE相比，PP和HHE的棘突层和颗粒层中的K5和K14表达水平更高。总合蛋白在PP和HHE的基底层中表达，但在CHE中不表达。与CHE相比,PP和HHE中的K9表达降低。
结论：表皮中角蛋白和总蛋白的表达是角质形成细胞分化的标志。HHE组和PP组之间角蛋白和总蛋白的表达水平相似，这表明HHE与PP而不是CHE具有共同的发病机制。
