Abstract：
Transcriptional corepressors form an ancient and essential layer of gene expression control in eukaryotes. TOPLESS and TOPLESS-RELATED (TPL/TPR) proteins constitute a conserved family of Groucho (Gro)/thymidine uptake 1 (Tup1)-type transcriptional corepressors and control diverse growth, developmental, and stress signaling responses in plants. Because of their central and versatile regulatory roles, they act as a signaling hub to integrate various input signaling pathways in the transcriptional responses. Recently, increasing pieces of evidence indicate the roles of TPL/TPR family proteins in the modulation of plant immunity. This is supported by studies on effectors of distantly related pathogens that target TPL/TPR proteins in planta. In this short review, we will summarize the latest findings concerning pathogens targeting plant TPL/TPR proteins to manipulate plant signaling responses for the successful invasion of their hosts. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
摘要：
转录抑制因子在真核生物中形成了古老而重要的基因表达控制层。无拓扑和无拓扑相关（TPL）/TPR）蛋白构成Groucho（Gro）/胸苷摄取1（Tup1）型转录抑制因子的保守家族，并控制多种生长，发展,和植物中的胁迫信号反应。由于它们的核心和多才多艺的监管作用，它们充当信号中枢，将各种输入信号通路整合到转录应答中。最近,越来越多的证据表明TPL/TPR家族蛋白在调节植物免疫中的作用。这得到了对植物中靶向TPL/TPR蛋白的远缘相关病原体的效应物的研究的支持。在这篇简短的评论中，我们将总结病原体靶向植物TPL/TPR蛋白以操纵植物信号传导反应以成功入侵其宿主的最新发现。
