PDF(Pubmed)
Abstract：
Tendinopathy (TP) is a complex clinical syndrome characterized by local inflammation, pain in the affected area, and loss of performance, preceded by tendon injury. The disease develops in three phases: Inflammatory phase, proliferative phase, and remodeling phase. There are currently no proven treatments for early reversal of this type of injury. However, the metabolic pathways of the transition metabolism, which are necessary for the proper functioning of the organism, are known. These metabolic pathways can be modified by a number of external factors, such as nutritional supplements. In this study, the modulatory effect of four dietary supplements, maslinic acid (MA), hydroxytyrosol (HT), glycine, and aspartate (AA), on hepatic intermediary metabolism was observed in Wistar rats with induced tendinopathy at different stages of the disease. Induced tendinopathy in rats produces alterations in the liver intermediary metabolism. Nutraceutical treatments modify the intermediary metabolism in the different phases of tendinopathy, so AA treatment produced a decrease in carbohydrate metabolism. In lipid metabolism, MA and AA caused a decrease in lipogenesis at the tendinopathy and increased fatty acid oxidation. In protein metabolism, MA treatment increased GDH and AST activity; HT decreased ALT activity; and the AA treatment does not cause any alteration. Use of nutritional supplements of diet could help to regulate the intermediary metabolism in the TP.
摘要：
肌腱病（TP）是一种以局部炎症为特征的复杂临床综合征，患处疼痛,和性能损失，在肌腱损伤之前。该疾病分为三个阶段：炎症阶段，增殖期，和重塑阶段。目前没有用于早期逆转这种类型损伤的已证实的治疗方法。然而,过渡代谢的代谢途径，这是生物体正常运作所必需的，是已知的。这些代谢途径可以被许多外部因素改变，如营养补充剂。在这项研究中,四种膳食补充剂的调节作用，山楂酸（MA），羟基酪醇（HT），甘氨酸,和天冬氨酸（AA），在疾病的不同阶段，在患有诱发性肌腱病的Wistar大鼠中观察到肝中介代谢。大鼠诱发的肌腱病导致肝脏中介代谢改变。营养疗法改变了肌腱病不同阶段的中间代谢，所以AA治疗导致碳水化合物代谢下降。在脂质代谢中，MA和AA引起肌腱病中脂肪生成的减少和脂肪酸氧化的增加。在蛋白质代谢中，MA处理增加GDH和AST活性;HT降低ALT活性;并且AA处理不引起任何改变。饮食中使用营养补充剂可以帮助调节TP中的中间代谢。
