PDF(Pubmed)
Abstract：
Chronic tendon and ligament diseases are commonly encountered in both athletic humans and animals, especially horses. Distal limb diseases, including suspensory ligament (SL) pathology due to anatomical, histological, and biomechanical properties, can be considered a model for tendon and ligament pathologies in humans. The appropriate selection of therapy is often crucial in optimising the healing process. One decisive factor influencing the possibility of returning to pre-disease training levels appears to be the utilisation of physical activity, including controlled movement, during the rehabilitation process. In the pathogenesis of musculoskeletal diseases and rehabilitation, adipocytokines play diverse roles. However, it is unclear what significance they hold in horses and in specific disease entities as well as the consequences of their mutual interactions. Recent studies indicate that in the pathogenesis of diseases with varied aetiologies in humans, their value varies at different stages, resulting in a diverse response to treatment. The results of this study demonstrate lower resistin concentrations in the venous blood plasma of horses with proximal suspensory desmopathy (PSD), while higher levels were observed in regularly trained and paddocked animals. The horses investigated in this study showed higher concentrations of resistin and IL-8, particularly in paddocked horses as well as in the working group of horses. The results suggest that these concentrations, including resistin in blood plasma, may be clinically significant. This attempt to explore the aetiopathogenesis of the processes occurring in the area of the proximal attachment of the suspensory ligament may optimise the procedures for the treatment and rehabilitation of horses.
摘要：
慢性肌腱和韧带疾病在运动人类和动物中都很常见，尤其是马。远端肢体疾病，包括由于解剖学引起的悬韧带（SL）病理，组织学,和生物力学特性，可以被认为是人类肌腱和韧带病变的模型。治疗的适当选择在优化愈合过程中通常是至关重要的。影响恢复到疾病前训练水平的可能性的一个决定性因素似乎是身体活动的利用，包括受控运动，在康复过程中。在肌肉骨骼疾病的发病机制和康复中，脂肪细胞因子发挥不同的作用。然而,目前尚不清楚它们在马和特定疾病实体中具有什么意义，以及它们相互作用的后果。最近的研究表明，在人类各种病因的疾病的发病机理中，它们的价值在不同阶段有所不同，导致对治疗的不同反应。这项研究的结果表明，患有近端悬吊性肾脏病（PSD）的马的静脉血浆中抵抗素浓度较低，而在定期训练和围场的动物中观察到更高的水平。在这项研究中研究的马显示出更高的抵抗素和IL-8浓度，特别是在停泊的马以及马的工作组中。结果表明，这些浓度，包括血浆中的抵抗素,可能具有临床意义。探索在悬韧带近端附着区域发生的过程的病因可能会优化马的治疗和康复程序。
