PDF(Pubmed)
Abstract：
Ischemic stroke is one of the most significant causes of morbidity and mortality worldwide. However, there is a dearth of effective drugs and treatment methods for ischemic stroke. Significant numbers of circular RNAs (circRNAs) exhibit abnormal expression following ischemic stroke and are considered potential therapeutic targets. CircRNAs have emerged as promising biomarkers due to their stable expression in peripheral blood and their potential significance in ischemic stroke diagnosis and prognosis. This review provides a summary of 31 circRNAs involved in the pathophysiological processes of apoptosis, autophagy, inflammation, oxidative stress, and angiogenesis following ischemic stroke. Furthermore, we discuss the mechanisms of action of said circRNAs and their potential clinical applications. Ultimately, circRNAs exhibit promise as both therapeutic targets and biomarkers for ischemic stroke.
摘要：
缺血性中风是世界范围内发病率和死亡率的最重要原因之一。然而,缺乏有效的缺血性中风药物和治疗方法。大量环状RNA（circularRNAs，circRNAs）在缺血性卒中后表现出异常表达，被认为是潜在的治疗靶点。由于其在外周血中的稳定表达及其在缺血性卒中诊断和预后中的潜在意义，CircRNAs已成为有希望的生物标志物。这篇综述总结了31个circRNAs参与细胞凋亡的病理生理过程。自噬,炎症,氧化应激，和缺血性中风后的血管生成。此外，我们讨论了circRNAs的作用机制及其潜在的临床应用。最终,circRNAs有望作为缺血性卒中的治疗靶标和生物标志物。
