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Abstract：
Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective cation channel protein, which can be activated by various physical and chemical stimuli. Recent studies have shown the strong pathogenetic associations of TRPV1 with neurodegenerative diseases (NDs), in particular Alzheimer\'s disease (AD), Parkinson\'s disease (PD) and multiple sclerosis (MS) via regulating neuroinflammation. Therapeutic effects of TRPV1 agonists and antagonists on the treatment of AD and PD in animal models also are emerging. We here summarize the current understanding of TRPV1\'s effects and its agonists and antagonists as a therapeutic means in neurodegenerative diseases, and highlight future treatment strategies using natural TRPV1 agonists. Developing new targets and applying natural products are becoming a promising direction in the treatment of chronic disorders, especially neurodegenerative diseases.
摘要：
瞬时受体电位香草酸1(TRPV1)是一种跨膜非选择性阳离子通道蛋白,它可以被各种物理和化学刺激激活。最近的研究表明，TRPV1与神经退行性疾病（ND）有很强的致病关联，特别是阿尔茨海默病（AD），帕金森病（PD）和多发性硬化症（MS）通过调节神经炎症。TRPV1激动剂和拮抗剂在动物模型中对AD和PD的治疗作用也正在出现。我们在这里总结了目前对TRPV1的作用及其激动剂和拮抗剂作为神经退行性疾病治疗手段的理解。并强调使用天然TRPV1激动剂的未来治疗策略。开发新的靶点,应用天然产物,正在成为慢性病治疗的一个有希望的方向,尤其是神经退行性疾病。
