PDF(Pubmed)
Abstract：
OBJECTIVE: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer.
METHODS: A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the association between HDAC-2 and the survival and clinicopathological features of the patients.
RESULTS: Increased HDAC-2 expression was observed in every fourth case of triple negative breast cancer with positive HDAC-2 staining, whereas only 12 out of 98 non-triple negative breast cancer samples showed high HDAC-2 expression. HDAC-2 overexpression correlated with prolonged overall survival (OS) and disease-free survival (DFS) in triple negative breast cancer.
CONCLUSIONS: High HDAC-2 levels in triple negative breast cancer seem to positively influence patient survival, disease stage and recurrence.
METHODS: A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the association between HDAC-2 and the survival and clinicopathological features of the patients.
RESULTS: Increased HDAC-2 expression was observed in every fourth case of triple negative breast cancer with positive HDAC-2 staining, whereas only 12 out of 98 non-triple negative breast cancer samples showed high HDAC-2 expression. HDAC-2 overexpression correlated with prolonged overall survival (OS) and disease-free survival (DFS) in triple negative breast cancer.
CONCLUSIONS: High HDAC-2 levels in triple negative breast cancer seem to positively influence patient survival, disease stage and recurrence.
摘要：
目的：三阴性乳腺癌属于最具侵袭性的乳腺癌形式。组蛋白脱乙酰酶（HDAC）构成了一类在乳腺癌发生和发展中具有重要作用的酶。在这项研究中,我们旨在评估HDAC-2在三阴性乳腺癌中的临床重要性.
方法：对138例乳腺癌标本进行免疫组织化学检查。进行统计分析以检查HDAC-2与患者的生存和临床病理特征之间的关联。
结果：在每4例HDAC-2染色阳性的三阴性乳腺癌中观察到HDAC-2表达增加，而98例非三阴性乳腺癌样本中只有12例显示高HDAC-2表达.HDAC-2过表达与三阴性乳腺癌的总生存期（OS）和无病生存期（DFS）延长相关。
结论：三阴性乳腺癌中的高HDAC-2水平似乎对患者的生存率有积极影响。疾病阶段和复发。
方法：对138例乳腺癌标本进行免疫组织化学检查。进行统计分析以检查HDAC-2与患者的生存和临床病理特征之间的关联。
结果：在每4例HDAC-2染色阳性的三阴性乳腺癌中观察到HDAC-2表达增加，而98例非三阴性乳腺癌样本中只有12例显示高HDAC-2表达.HDAC-2过表达与三阴性乳腺癌的总生存期（OS）和无病生存期（DFS）延长相关。
结论：三阴性乳腺癌中的高HDAC-2水平似乎对患者的生存率有积极影响。疾病阶段和复发。
