PDF(Pubmed)
Abstract：
Squamous cell carcinoma of the nasal vestibule is considered a rare malignancy that differs from other sinonasal malignancies in many respects. Four staging systems currently exist for this disease, the most recent addition being the \"Rome\" classification. This study assesses the use of this new classification and its prognostic value regarding various outcome measures. A retrospective multicenter cohort study of patients with a primary squamous cell carcinoma of the nasal vestibule who were treated in three tertiary head and neck oncology referral centers was conducted. A total of 149 patients were included. The median follow-up duration was 27 months. Five-year locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS) were 81.6%, 90.1, and 62.5% respectively. A statistically significant association was observed between the Rome classification and all survival outcomes in both univariable and multivariable analyses. Moreover, it appeared to perform better than the Union for International Cancer Control TNM classification for tumors of the nasal cavity and paranasal sinuses. The new Rome classification can be used effectively and is associated with LRC, DSS, and OS. However, it requires further validation in a larger (prospective) study population.
摘要：
鼻前庭鳞状细胞癌被认为是一种罕见的恶性肿瘤，在许多方面与其他鼻窦恶性肿瘤不同。目前这种疾病有四种分期系统，最近增加的是“罗马”分类。这项研究评估了这种新分类的使用及其对各种结局指标的预后价值。对在三个三级头颈部肿瘤转诊中心接受治疗的鼻前庭原发性鳞状细胞癌患者进行了回顾性多中心队列研究。共纳入149例患者。中位随访时间为27个月。五年局部控制(LRC)，疾病特异性生存率（DSS），总生存率（OS）为81.6%，分别为90.1和62.5%。在单变量和多变量分析中，罗马分类与所有生存结果之间观察到统计学上的显着关联。此外，对于鼻腔和鼻旁窦肿瘤，它的表现似乎优于国际癌症控制联盟的TNM分类。新的罗马分类可以有效地使用，并与LRC相关联，DSS,和OS。然而,它需要在更大的(前瞻性)研究人群中进一步验证.
