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Abstract：
The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg (p < 0.001) and 15.4 ± 0.7 mmHg (p = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: -11.5 ± 0.9 dB to -12.0 ± 1.1 (p = 0.090); DS: -10.5 ± 0.9 dB to -11.0 ± 1.0 dB (p = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm (p < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm (p < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up.
摘要：
这项研究的目的是比较小梁切除术（TE）和深层巩膜切除术（DS）在降低眼压（IOP），从而保留视野和乳头周围视网膜神经纤维层（RNFL）组织的原发性开角型青光眼（POAG）病例的有效性。IOP,降低IOP的药物数量，视敏度,标准自动视野检查的平均缺陷，回顾性收集和平均乳头周围RNFL厚度，术后随访3年。TE在104只眼中进行，DS在183只眼中进行。年龄,性别,偏侧性,IOP,药物的数量,视敏度,视野检查平均缺陷，和乳头周围RNFL厚度在基线上均匀分布。TE组和DS组的平均眼压从23.8±1.4mmHg和23.1±0.4mmHg降至13.4±0.6mmHg(p<0.001)和15.4±0.7mmHg(p=0.001),分别。平均缺陷保持稳定（TE：-11.5±0.9dB至-12.0±1.1（p=0.090）；DS：-10.5±0.9dB至-11.0±1.0dB（p=0.302）），而平均乳头周围RNFL厚度在随访期间显示进一步恶化（TE组：64.4±2.1μm至59.7±3.5μm（p<0.001）；DS组：64.9±1.9μm至58.4±2.1μm（p<0.001））。TE和DS在降低术后IOP和药物治疗方面均相当有效。然而,青光眼疾病在随访期间进一步进展。
