Abstract：
Various conventional treatments including endocrine therapy, radiotherapy, surgery, and chemotherapy have been used for several decades to treat breast cancer; however, these therapies exhibit various life-threatening and debilitating adverse effects in patients. Additionally, combination therapies are required for prompt action as well as to prevent drug resistance toward standard breast cancer medications. Ferrite nanoparticles (NPs) are increasingly gaining momentum for their application in the diagnosis and treatment of breast cancer. Spinel ferrites are particularly used against breast cancer and have shown in vitro and in vivo better efficacy as compared to conventional cancer therapies. Magnetic resonance imaging contrast agents, magnetic particle imaging tracers, cell separation, and immune assays are some aspects related to the diagnosis of breast cancer against which different ferrite NPs have been successfully evaluated. Moreover, citrate-coated nickel ferrite, Mg/Zn ferrites, poly amidoamine dendrimers, cobalt ferrites, graphene oxide cobalt ferrites, doxorubicin functionalized cobalt ferrites, chitosan-coated zinc ferrites, PEG-coated cobalt ferrite, and copper ferrite NPs have demonstrated antiproliferative action against different breast cancer cells. Oxaliplatin-loaded polydopamine/BSA-copper ferrites, functionalized cobalt and zinc ferrites of curcumin, oxaliplatin-copper ferrite NPs, tamoxifen/diosgenin encapsulated ZnO/Mn ferrites, and fabricated core-shell fibers of doxorubicin have been developed to increase the bioavailability and anti-proliferative effect and decrease the toxicity of anticancer drugs. These ferrite NPs showed an anticancer effect at different doses in the presence or absence of an external magnetic field. The present review covers the in-depth investigations of ferrite NPs for the diagnosis and management of breast cancer.
摘要：
各种常规治疗包括内分泌治疗，放射治疗,手术,和化疗已经使用了几十年来治疗乳腺癌;然而，这些疗法对患者表现出各种危及生命和使人衰弱的不良反应。此外,需要联合治疗才能迅速采取行动，并防止对标准乳腺癌药物的耐药性。铁氧体纳米粒子（NPs）在乳腺癌的诊断和治疗中的应用正日益获得动力。尖晶石铁氧体特别用于对抗乳腺癌,并且与常规癌症疗法相比在体外和体内显示出更好的功效。磁共振成像造影剂,磁性粒子成像示踪剂，细胞分离,和免疫测定是与乳腺癌诊断相关的一些方面，已成功评估了不同的铁氧体NP。此外，柠檬酸盐涂层镍铁氧体，Mg/Zn铁氧体，聚酰胺胺树枝状高分子，钴铁氧体，氧化石墨烯钴铁氧体，多柔比星功能化的钴铁氧体，壳聚糖包覆的锌铁氧体，PEG涂层钴铁氧体，和铜铁氧体NP已经证明了对不同乳腺癌细胞的抗增殖作用。负载奥沙利铂的聚多巴胺/BSA-铜铁氧体，姜黄素的功能化钴和锌铁氧体，奥沙利铂-铜铁氧体NP，他莫昔芬/薯白皂苷元包封的ZnO/Mn铁氧体，已经开发了多柔比星的核壳纤维，以提高生物利用度和抗增殖作用，并降低抗癌药物的毒性。在存在或不存在外部磁场的情况下，这些铁氧体NP在不同剂量下显示出抗癌作用。本综述涵盖了铁氧体NP在乳腺癌诊断和治疗中的深入研究。
