Abstract：
UNASSIGNED: Morning dry mouth, commonly seen in Obstructive Sleep Apnea (OSA) patients, is absent in current OSA screening tools. This study evaluated the link between morning dry mouth and OSA\'s clinical symptoms and complications, aiming to determine its viability as a screening indicator.
UNASSIGNED: This research analyses baseline data from a prospective cohort study (the PIFCOPD study). Demographic information, medical history, and the presence of morning dry mouth symptoms were collected. The STOP-Bang questionnaire was performed for OSA screening. Logistic regression analyses were employed to establish the correlations between morning dry mouth and the clinical symptoms and comorbidities of OSA.
UNASSIGNED: 1291 participants (62.1±7.5 years; 501 males, 790 females) were included, of which 416 reported morning dry mouth (32.2%). 42.6% in the high-risk OSA group and 22.1% in the low-risk group reported morning dry mouth. Individuals with morning dry mouth also showed higher STOP-Bang scores (3.3±1.6 vs. 2.3±1.4, P<0.01). Significant associations were found between morning dry mouth and loud snoring, observed sleep apnea, daytime fatigue, and hyperlipidemia (P<0.01), but not with alcohol consumption, tea consumption, diabetes, or hypertension.
UNASSIGNED: Morning dry mouth is associated with increased OSA risk and its clinical signs, suggesting its potential as an OSA screening symptom.
UNASSIGNED: This study has been registered at www.ClinicalTrials.gov (registration identifier: NCT03532893) on 21 May 2018.
UNASSIGNED: This research analyses baseline data from a prospective cohort study (the PIFCOPD study). Demographic information, medical history, and the presence of morning dry mouth symptoms were collected. The STOP-Bang questionnaire was performed for OSA screening. Logistic regression analyses were employed to establish the correlations between morning dry mouth and the clinical symptoms and comorbidities of OSA.
UNASSIGNED: 1291 participants (62.1±7.5 years; 501 males, 790 females) were included, of which 416 reported morning dry mouth (32.2%). 42.6% in the high-risk OSA group and 22.1% in the low-risk group reported morning dry mouth. Individuals with morning dry mouth also showed higher STOP-Bang scores (3.3±1.6 vs. 2.3±1.4, P<0.01). Significant associations were found between morning dry mouth and loud snoring, observed sleep apnea, daytime fatigue, and hyperlipidemia (P<0.01), but not with alcohol consumption, tea consumption, diabetes, or hypertension.
UNASSIGNED: Morning dry mouth is associated with increased OSA risk and its clinical signs, suggesting its potential as an OSA screening symptom.
UNASSIGNED: This study has been registered at www.ClinicalTrials.gov (registration identifier: NCT03532893) on 21 May 2018.
摘要：
■早晨口干，常见于阻塞性睡眠呼吸暂停（OSA）患者，在当前的OSA筛查工具中不存在。这项研究评估了早晨口干与OSA的临床症状和并发症之间的联系，旨在确定其作为筛选指标的可行性。
■本研究分析了一项前瞻性队列研究（PIFCOPD研究）的基线数据。人口统计信息,病史,并收集早晨口干症状的存在。使用STOP-Bang问卷进行OSA筛查。采用Logistic回归分析建立早晨口干与OSA临床症状和合并症之间的相关性。
■1291名参与者（62.1±7.5岁；501名男性，包括790名女性），其中416人报告早上口干(32.2%)。高危OSA组的42.6％和低危组的22.1％报告了口干。早晨口干的个体也显示出更高的STOP-Bang评分（3.3±1.6vs.2.3±1.4，P<0.01）。发现早晨口干和大声打鼾之间存在显着关联，观察到的睡眠呼吸暂停，白天疲劳,和高脂血症（P<0.01），但不是饮酒，茶叶消费,糖尿病,或高血压。
■早晨口干与OSA风险及其临床体征增加有关，提示其作为OSA筛查症状的潜力。
■这项研究已在www注册。ClinicalTrials.gov（注册标识符：NCT03532893）于2018年5月21日发布。
■本研究分析了一项前瞻性队列研究（PIFCOPD研究）的基线数据。人口统计信息,病史,并收集早晨口干症状的存在。使用STOP-Bang问卷进行OSA筛查。采用Logistic回归分析建立早晨口干与OSA临床症状和合并症之间的相关性。
■1291名参与者（62.1±7.5岁；501名男性，包括790名女性），其中416人报告早上口干(32.2%)。高危OSA组的42.6％和低危组的22.1％报告了口干。早晨口干的个体也显示出更高的STOP-Bang评分（3.3±1.6vs.2.3±1.4，P<0.01）。发现早晨口干和大声打鼾之间存在显着关联，观察到的睡眠呼吸暂停，白天疲劳,和高脂血症（P<0.01），但不是饮酒，茶叶消费,糖尿病,或高血压。
■早晨口干与OSA风险及其临床体征增加有关，提示其作为OSA筛查症状的潜力。
■这项研究已在www注册。ClinicalTrials.gov（注册标识符：NCT03532893）于2018年5月21日发布。
