Abstract：
There is growing evidence regarding the prognostic utility of ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIII) in head and neck squamous cell carcinoma (HNSCC). However, most studies to date include heterogeneous series with different treatments or tumor subsites.
We collected data from 201 patients with stage I-II glottic squamous cell carcinoma treated with transoral laser surgery. NLR, PLR, and SIII were calculated from preoperative cell blood count, cut-off points were obtained by ROC curve analysis, and survival rates were calculated.
High NLR (p = 0.012) and SIII (p = 0.037), but not PLR (p = 0.48), were associated with worse disease-specific survival (DSS). A similar trend was observed with overall survival (OS), although it did not reach statistical significance. On multivariable analyses, both high NLR (HR = 3.8, 95% CI = 1.5-9.9, p = 0.006) and high SIII (HR = 2.77, 95% CI = 1.1-6.9, p = 0.03) were significantly associated with shortened DSS.
Preoperative NLR and SIII emerge as independent prognostic biomarkers for early-stage surgically treated glottic tumors and could guide individualized follow-up.
We collected data from 201 patients with stage I-II glottic squamous cell carcinoma treated with transoral laser surgery. NLR, PLR, and SIII were calculated from preoperative cell blood count, cut-off points were obtained by ROC curve analysis, and survival rates were calculated.
High NLR (p = 0.012) and SIII (p = 0.037), but not PLR (p = 0.48), were associated with worse disease-specific survival (DSS). A similar trend was observed with overall survival (OS), although it did not reach statistical significance. On multivariable analyses, both high NLR (HR = 3.8, 95% CI = 1.5-9.9, p = 0.006) and high SIII (HR = 2.77, 95% CI = 1.1-6.9, p = 0.03) were significantly associated with shortened DSS.
Preoperative NLR and SIII emerge as independent prognostic biomarkers for early-stage surgically treated glottic tumors and could guide individualized follow-up.
摘要：
背景：关于中性粒细胞与淋巴细胞比率（NLR）等比率的预后效用，血小板与淋巴细胞比率（PLR），头颈部鳞状细胞癌（HNSCC）的全身免疫炎症指数（SIII）。然而,迄今为止，大多数研究包括具有不同治疗或肿瘤亚位点的异质系列。
方法：我们收集了201例经口腔激光手术治疗的I-II期声门鳞状细胞癌患者的数据。NLR,PLR,SIII是根据术前细胞血细胞计数计算的，通过ROC曲线分析获得临界点，并计算生存率。
结果：高NLR（p=0.012）和SIII（p=0.037），但不是PLR（p=0.48），与较差的疾病特异性生存率（DSS）相关。在总生存期（OS）中观察到类似的趋势，虽然没有达到统计学意义。在多变量分析中，高NLR(HR=3.8,95%CI=1.5-9.9,p=0.006)和高SIII(HR=2.77,95%CI=1.1-6.9,p=0.03)均与DSS缩短显著相关.
结论：术前NLR和SIII是早期手术治疗声门型肿瘤的独立预后生物标志物，可以指导个体化随访。
方法：我们收集了201例经口腔激光手术治疗的I-II期声门鳞状细胞癌患者的数据。NLR,PLR,SIII是根据术前细胞血细胞计数计算的，通过ROC曲线分析获得临界点，并计算生存率。
结果：高NLR（p=0.012）和SIII（p=0.037），但不是PLR（p=0.48），与较差的疾病特异性生存率（DSS）相关。在总生存期（OS）中观察到类似的趋势，虽然没有达到统计学意义。在多变量分析中，高NLR(HR=3.8,95%CI=1.5-9.9,p=0.006)和高SIII(HR=2.77,95%CI=1.1-6.9,p=0.03)均与DSS缩短显著相关.
结论：术前NLR和SIII是早期手术治疗声门型肿瘤的独立预后生物标志物，可以指导个体化随访。
