We collected data from 201 patients with stage I-II glottic squamous cell carcinoma treated with transoral laser surgery. NLR, PLR, and SIII were calculated from preoperative cell blood count, cut-off points were obtained by ROC curve analysis, and survival rates were calculated.
High NLR (p = 0.012) and SIII (p = 0.037), but not PLR (p = 0.48), were associated with worse disease-specific survival (DSS). A similar trend was observed with overall survival (OS), although it did not reach statistical significance. On multivariable analyses, both high NLR (HR = 3.8, 95% CI = 1.5-9.9, p = 0.006) and high SIII (HR = 2.77, 95% CI = 1.1-6.9, p = 0.03) were significantly associated with shortened DSS.
Preoperative NLR and SIII emerge as independent prognostic biomarkers for early-stage surgically treated glottic tumors and could guide individualized follow-up.
方法:我们收集了201例经口腔激光手术治疗的I-II期声门鳞状细胞癌患者的数据。NLR,PLR,SIII是根据术前细胞血细胞计数计算的,通过ROC曲线分析获得临界点,并计算生存率。
结果:高NLR(p=0.012)和SIII(p=0.037),但不是PLR(p=0.48),与较差的疾病特异性生存率(DSS)相关。在总生存期(OS)中观察到类似的趋势,虽然没有达到统计学意义。在多变量分析中,高NLR(HR=3.8,95%CI=1.5-9.9,p=0.006)和高SIII(HR=2.77,95%CI=1.1-6.9,p=0.03)均与DSS缩短显著相关.
结论:术前NLR和SIII是早期手术治疗声门型肿瘤的独立预后生物标志物,可以指导个体化随访。