PDF(Pubmed)
Abstract：
UNASSIGNED: We investigate the correlation between glucose and lipid metabolism and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) and its diagnostic and predictive value.
UNASSIGNED: A retrospective analysis involved 620 patients diagnosed with T2DM, categorized into two groups based on fundus examination results: the non-diabetic retinopathy group (NDR, n=340) and the diabetic retinopathy group (DR, n=280). We collected baseline patient data, calculated the ratio of glycated hemoglobin (HbA1c) to high-density lipoprotein cholesterol (HDL-C), and analyzed its association with Type 2 Diabetic Retinopathy.
UNASSIGNED: HbA1c/HDL-C in DR group exhibited significantly higher than the NDR group (P<0.001). Mantel-Haenszel\'s chi-square trend analysis indicated a notable linear trend (P<0.001) between HbA1c/HDL-C and DR. HbA1c/HDL-C revealed moderate positive correlations with DR, r=0.342, P<0.001. Binary logistic regression analysis showed systolic blood pressure (SBP), diabetes course, fasting blood glucose (FBG) and HbA1c/HDL-C as independent risk factors for DR in T2DM patients. Restrictive cubic spline analysis demonstrated a significant nonlinear relationship between HbA1c/HDL-C and DR (P total trend <0.001, P nonlinear = 0.0196). ROC curve analysis identified that HbA1c/HDL-C had the highest diagnostic accuracy for DR, with an area under the ROC curve (AUC) of 0.711, 53.2% sensitivity, and 78.2% specificity.
UNASSIGNED: Our study shows that HbA1c/HDL-C is an independent risk factor for DR in patients with type 2 diabetes. HbA1c/HDL-C has good diagnostic value for DR and can be used as a biological index for early screening of DR.
UNASSIGNED: A retrospective analysis involved 620 patients diagnosed with T2DM, categorized into two groups based on fundus examination results: the non-diabetic retinopathy group (NDR, n=340) and the diabetic retinopathy group (DR, n=280). We collected baseline patient data, calculated the ratio of glycated hemoglobin (HbA1c) to high-density lipoprotein cholesterol (HDL-C), and analyzed its association with Type 2 Diabetic Retinopathy.
UNASSIGNED: HbA1c/HDL-C in DR group exhibited significantly higher than the NDR group (P<0.001). Mantel-Haenszel\'s chi-square trend analysis indicated a notable linear trend (P<0.001) between HbA1c/HDL-C and DR. HbA1c/HDL-C revealed moderate positive correlations with DR, r=0.342, P<0.001. Binary logistic regression analysis showed systolic blood pressure (SBP), diabetes course, fasting blood glucose (FBG) and HbA1c/HDL-C as independent risk factors for DR in T2DM patients. Restrictive cubic spline analysis demonstrated a significant nonlinear relationship between HbA1c/HDL-C and DR (P total trend <0.001, P nonlinear = 0.0196). ROC curve analysis identified that HbA1c/HDL-C had the highest diagnostic accuracy for DR, with an area under the ROC curve (AUC) of 0.711, 53.2% sensitivity, and 78.2% specificity.
UNASSIGNED: Our study shows that HbA1c/HDL-C is an independent risk factor for DR in patients with type 2 diabetes. HbA1c/HDL-C has good diagnostic value for DR and can be used as a biological index for early screening of DR.
摘要：
■我们研究了2型糖尿病（T2DM）患者糖脂代谢与糖尿病视网膜病变（DR）的相关性及其诊断和预测价值。
■回顾性分析包括620名诊断为T2DM的患者，根据眼底检查结果分为两组:非糖尿病性视网膜病变组(NDR,n=340）和糖尿病视网膜病变组（DR，n=280）。我们收集了基线患者数据，计算糖化血红蛋白（HbA1c）与高密度脂蛋白胆固醇（HDL-C）的比值，并分析其与2型糖尿病视网膜病变的关系。
■DR组HbA1c/HDL-C明显高于NDR组(P<0.001)。Mantel-Haenszel的卡方趋势分析显示HbA1c/HDL-C与DR呈显著的线性趋势(P<0.001)。HbA1c/HDL-C与DR呈中度正相关，r=0.342,P<0.001。二元logistic回归分析显示收缩压（SBP），糖尿病病程,空腹血糖（FBG）和HbA1c/HDL-C是T2DM患者DR的独立危险因素。限制性三次样条分析表明HbA1c/HDL-C与DR之间存在显着的非线性关系（P总趋势<0.001，P非线性=0.0196）。ROC曲线分析发现HbA1c/HDL-C对DR的诊断准确率最高,ROC曲线下面积（AUC）为0.711，灵敏度为53.2%，和78.2%的特异性。
■我们的研究表明，HbA1c/HDL-C是2型糖尿病患者发生DR的独立危险因素。HbA1c/HDL-C对DR具有良好的诊断价值,可作为DR早期筛查的生物学指标。
■回顾性分析包括620名诊断为T2DM的患者，根据眼底检查结果分为两组:非糖尿病性视网膜病变组(NDR,n=340）和糖尿病视网膜病变组（DR，n=280）。我们收集了基线患者数据，计算糖化血红蛋白（HbA1c）与高密度脂蛋白胆固醇（HDL-C）的比值，并分析其与2型糖尿病视网膜病变的关系。
■DR组HbA1c/HDL-C明显高于NDR组(P<0.001)。Mantel-Haenszel的卡方趋势分析显示HbA1c/HDL-C与DR呈显著的线性趋势(P<0.001)。HbA1c/HDL-C与DR呈中度正相关，r=0.342,P<0.001。二元logistic回归分析显示收缩压（SBP），糖尿病病程,空腹血糖（FBG）和HbA1c/HDL-C是T2DM患者DR的独立危险因素。限制性三次样条分析表明HbA1c/HDL-C与DR之间存在显着的非线性关系（P总趋势<0.001，P非线性=0.0196）。ROC曲线分析发现HbA1c/HDL-C对DR的诊断准确率最高,ROC曲线下面积（AUC）为0.711，灵敏度为53.2%，和78.2%的特异性。
■我们的研究表明，HbA1c/HDL-C是2型糖尿病患者发生DR的独立危险因素。HbA1c/HDL-C对DR具有良好的诊断价值,可作为DR早期筛查的生物学指标。
