PDF(Pubmed)
Abstract：
In the past 25 years, a vast family of complex organic salts known as room-temperature ionic liquids (ILs) has received increasing attention due to their potential applications. ILs are composed by an organic cation and either an organic or inorganic anion, and possess several intriguing properties such as low vapor pressure and being liquid around room temperature. Several biological studies flagged their moderate-to-high (cyto)-toxicity. Toxicity is, however, also a synonym of affinity, and this boosted a series of biophysical and chemical-physical investigations aimed at exploiting ILs in bio-nanomedicine, drug-delivery, pharmacology, and bio-nanotechnology. Several of these investigations focused on the interaction between ILs and lipid membranes, aimed at determining the microscopic mechanisms behind their interaction. This is the focus of this review work. These studies have been carried out on a variety of different lipid bilayer systems ranging from 1-lipid to 5-lipids systems, and also on cell-extracted membranes. They have been carried out at different chemical-physical conditions and by the use of a number of different approaches, including atomic force microscopy, neutron and X-ray scattering, dynamic light scattering, differential scanning calorimetry, surface quartz microbalance, nuclear magnetic resonance, confocal fluorescence microscopy, and molecular dynamics simulations. The aim of this \"2023 Michèle Auger Award\" review work is to provide the reader with an up-to-date overview of this fascinating research field where \"ILs meet lipid bilayers (aka biomembranes),\" with the aim to boost it further and expand its cross-disciplinary edges towards novel high-impact ideas/applications in pharmacology, drug delivery, biomedicine, and bio-nanotechnology.
摘要：
在过去的25年里,被称为室温离子液体(IL)的复杂有机盐的巨大家族由于其潜在的应用而受到越来越多的关注。IL由有机阳离子和有机或无机阴离子组成，并且具有一些有趣的特性，例如低蒸气压和在室温下为液体。一些生物学研究标记了它们的中高（cyto）毒性。毒性是,然而,也是亲和力的同义词，这促进了一系列旨在利用生物纳米医学中的IL的生物物理和化学物理研究，药物输送,药理学,和生物纳米技术。其中一些研究集中在IL和脂质膜之间的相互作用，旨在确定它们相互作用背后的微观机制。这是本次审查工作的重点。这些研究已经在从1-脂质到5-脂质系统的各种不同的脂质双层系统上进行，也在细胞提取的膜上。它们是在不同的化学物理条件下进行的，并使用了许多不同的方法，包括原子力显微镜,中子和X射线散射,动态光散射,差示扫描量热法,表面石英微天平，核磁共振,共聚焦荧光显微镜，和分子动力学模拟。“2023年MichèleAuger奖”评审工作的目的是为读者提供这个迷人的研究领域的最新概述，“IL满足脂质双层（又名生物膜），“目的是进一步推动它，并扩大其跨学科的边缘，使其在药理学中具有新的高影响力的想法/应用，药物输送,生物医学,和生物纳米技术。
