PDF(Pubmed)
Abstract：
BACKGROUND: Brucellosis is a zoonotic affliction instigated by bacteria belonging to the genus Brucella and is characterized by a diverse range of pervasiveness, multiple transmission routes, and serious hazards. It is imperative to amalgamate the current knowledge and identify gaps pertaining to the role of ticks in brucellosis transmission.
METHODS: We systematically searched China National Knowledge Infrastructure (CNKI), WanFang, Google Scholar, and PubMed on the topic published until April 23, 2022. The procedure was performed in accordance with the Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The selected articles were categorized across three major topic areas, and the potential data was extracted to describe evidence-practice gaps by two reviewers.
RESULTS: The search identified 83 eligible studies for the final analyses. The results highlighted the potential capacity of ticks in brucellosis transmission as evidenced by the detection of Brucella in 16 different tick species. The pooled overall prevalence of Brucella in ticks was 33.87% (range: 0.00-87.80%). The review also revealed the capability of Brucella to circulate in parasitic ticks\' different developmental stages, thus posing a potential threat to animal and human health. Empirical evidence from in vitro rodent infection experiments has revealed that ticks possess the capability to transmit Brucella to uninfected animals (range: 45.00-80.00%). Moreover, significant epidemiological associations have been found between the occurrence of brucellosis in animals and tick control in rangelands, which further suggests that ticks may serve as potential vectors for brucellosis transmission in ruminants. Notably, a mere three cases of human brucellosis resulting from potential tick bites were identified in search of global clinical case reports from 1963 to 2019.
CONCLUSIONS: It is imperative to improve the techniques used to identify Brucella in ticks, particularly by developing a novel, efficient, precise approach that can be applied in a field setting. Furthermore, due to the lack of adequate evidence of tick-borne brucellosis, it is essential to integrate various disciplines, including experimental animal science, epidemiology, molecular genetics, and others, to better understand the efficacy of tick-borne brucellosis. By amalgamating multiple disciplines, we can enhance our comprehension and proficiency in tackling tick-borne brucellosis.
METHODS: We systematically searched China National Knowledge Infrastructure (CNKI), WanFang, Google Scholar, and PubMed on the topic published until April 23, 2022. The procedure was performed in accordance with the Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The selected articles were categorized across three major topic areas, and the potential data was extracted to describe evidence-practice gaps by two reviewers.
RESULTS: The search identified 83 eligible studies for the final analyses. The results highlighted the potential capacity of ticks in brucellosis transmission as evidenced by the detection of Brucella in 16 different tick species. The pooled overall prevalence of Brucella in ticks was 33.87% (range: 0.00-87.80%). The review also revealed the capability of Brucella to circulate in parasitic ticks\' different developmental stages, thus posing a potential threat to animal and human health. Empirical evidence from in vitro rodent infection experiments has revealed that ticks possess the capability to transmit Brucella to uninfected animals (range: 45.00-80.00%). Moreover, significant epidemiological associations have been found between the occurrence of brucellosis in animals and tick control in rangelands, which further suggests that ticks may serve as potential vectors for brucellosis transmission in ruminants. Notably, a mere three cases of human brucellosis resulting from potential tick bites were identified in search of global clinical case reports from 1963 to 2019.
CONCLUSIONS: It is imperative to improve the techniques used to identify Brucella in ticks, particularly by developing a novel, efficient, precise approach that can be applied in a field setting. Furthermore, due to the lack of adequate evidence of tick-borne brucellosis, it is essential to integrate various disciplines, including experimental animal science, epidemiology, molecular genetics, and others, to better understand the efficacy of tick-borne brucellosis. By amalgamating multiple disciplines, we can enhance our comprehension and proficiency in tackling tick-borne brucellosis.
摘要：
背景：布鲁氏菌病是由布鲁氏菌属细菌引起的人畜共患疾病，其特征是具有多种普遍性，多条传输路线，和严重的危险。必须合并当前的知识，并确定与蜱在布鲁氏菌病传播中的作用有关的差距。
方法：我们系统地搜索了中国国家知识基础设施(CNKI)，万方,谷歌学者，和PubMed关于该主题的文章发布至2022年4月23日。该程序是根据系统审查和Meta分析扩展范围审查（PRISMA-ScR）指南进行的。选定的文章分为三个主要主题领域，并提取了潜在的数据来描述两名审查员的证据-实践差距。
结果：搜索确定了83个合格的最终分析研究。结果强调了蜱在布鲁氏菌病传播中的潜在能力，如在16种不同蜱种中检测到的布鲁氏菌所证明的。蜱中布鲁氏菌的总体患病率为33.87%(范围:0.00-87.80%)。该综述还揭示了布鲁氏菌在寄生蜱的不同发育阶段循环的能力，从而对动物和人类健康构成潜在威胁。来自体外啮齿动物感染实验的经验证据表明，蜱具有将布鲁氏菌传播给未感染动物的能力（范围：45.00-80.00％）。此外，已发现动物布鲁氏菌病的发生与牧场的蜱虫控制之间存在显著的流行病学关联，这进一步表明，蜱可能是布鲁氏菌病在反刍动物中传播的潜在载体。值得注意的是,在搜索1963年至2019年的全球临床病例报告时，仅发现了3例由潜在蜱叮咬引起的人类布鲁氏菌病。
结论：必须改进用于识别蜱中布鲁氏菌的技术，特别是通过开发小说，高效,可应用于现场设置的精确方法。此外，由于缺乏蜱传布鲁氏菌病的充分证据，整合各个学科至关重要，包括实验动物科学，流行病学,分子遗传学,和其他人,更好地了解蜱传布鲁氏菌病的疗效。通过合并多个学科，我们可以提高我们应对蜱传布鲁氏菌病的理解和熟练程度。
方法：我们系统地搜索了中国国家知识基础设施(CNKI)，万方,谷歌学者，和PubMed关于该主题的文章发布至2022年4月23日。该程序是根据系统审查和Meta分析扩展范围审查（PRISMA-ScR）指南进行的。选定的文章分为三个主要主题领域，并提取了潜在的数据来描述两名审查员的证据-实践差距。
结果：搜索确定了83个合格的最终分析研究。结果强调了蜱在布鲁氏菌病传播中的潜在能力，如在16种不同蜱种中检测到的布鲁氏菌所证明的。蜱中布鲁氏菌的总体患病率为33.87%(范围:0.00-87.80%)。该综述还揭示了布鲁氏菌在寄生蜱的不同发育阶段循环的能力，从而对动物和人类健康构成潜在威胁。来自体外啮齿动物感染实验的经验证据表明，蜱具有将布鲁氏菌传播给未感染动物的能力（范围：45.00-80.00％）。此外，已发现动物布鲁氏菌病的发生与牧场的蜱虫控制之间存在显著的流行病学关联，这进一步表明，蜱可能是布鲁氏菌病在反刍动物中传播的潜在载体。值得注意的是,在搜索1963年至2019年的全球临床病例报告时，仅发现了3例由潜在蜱叮咬引起的人类布鲁氏菌病。
结论：必须改进用于识别蜱中布鲁氏菌的技术，特别是通过开发小说，高效,可应用于现场设置的精确方法。此外，由于缺乏蜱传布鲁氏菌病的充分证据，整合各个学科至关重要，包括实验动物科学，流行病学,分子遗传学,和其他人,更好地了解蜱传布鲁氏菌病的疗效。通过合并多个学科，我们可以提高我们应对蜱传布鲁氏菌病的理解和熟练程度。
