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Abstract：
BACKGROUND: Serum tumor markers (STM), extensively used for the diagnosis, monitoring and prognostic assessment of tumors, can be increased in some non-malignant lung diseases. To date, there is a paucity of studies regarding the clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive STMs.
OBJECTIVE: To investigate the clinical characteristics and indicators of bronchiectasis with positive STMs.
METHODS: The clinical data of 377 bronchiectasis patients was retrospectively collected from January 2017 to December 2019 from Beijing Chaoyang Hospital. Patients were divided into the STM negative group, the single STM positive group and the ≥2 STMs positive group according to the number of the positive STMs. The clinical characteristics are described and compared separately. The multivariate logistic regression analysis model was used to investigate the indicators regarding positive STMs.
RESULTS: Patients in the ≥2 STMs positive group were older (P = 0.015), had higher mMRC scores (P < 0.001) and developed higher fever (P = 0.027). Additionally, these patients also had lower Albumin/Globulin Ratio (A/G), albumin (ALB), prealbumin (PAB) (P < 0.001, P < 0.001, P < 0.001, respectively) and higher CRP, ESR and Fbg (P < 0.001, P < 0.001 and P < 0.001, respectively). Age (OR 1.022, 95%CI 1.003-1.042; P = 0.026) and the number of affected lobes (OR 1.443, 95%CI 1.233-1.690; P < 0.001) were independently associated with one and ≥ 2 positive STMs in bronchiectasis patients.
CONCLUSIONS: The ≥2 positive STMs are associated with a higher inflammation status and severer radiologic manifestations in bronchiectasis patients.
OBJECTIVE: To investigate the clinical characteristics and indicators of bronchiectasis with positive STMs.
METHODS: The clinical data of 377 bronchiectasis patients was retrospectively collected from January 2017 to December 2019 from Beijing Chaoyang Hospital. Patients were divided into the STM negative group, the single STM positive group and the ≥2 STMs positive group according to the number of the positive STMs. The clinical characteristics are described and compared separately. The multivariate logistic regression analysis model was used to investigate the indicators regarding positive STMs.
RESULTS: Patients in the ≥2 STMs positive group were older (P = 0.015), had higher mMRC scores (P < 0.001) and developed higher fever (P = 0.027). Additionally, these patients also had lower Albumin/Globulin Ratio (A/G), albumin (ALB), prealbumin (PAB) (P < 0.001, P < 0.001, P < 0.001, respectively) and higher CRP, ESR and Fbg (P < 0.001, P < 0.001 and P < 0.001, respectively). Age (OR 1.022, 95%CI 1.003-1.042; P = 0.026) and the number of affected lobes (OR 1.443, 95%CI 1.233-1.690; P < 0.001) were independently associated with one and ≥ 2 positive STMs in bronchiectasis patients.
CONCLUSIONS: The ≥2 positive STMs are associated with a higher inflammation status and severer radiologic manifestations in bronchiectasis patients.
摘要：
背景：血清肿瘤标志物（STM），广泛用于诊断，肿瘤的监测和预后评估，在一些非恶性肺部疾病中可以增加。迄今为止,关于STMs阳性的非囊性纤维化支气管扩张患者的临床特征的研究很少。
目的：研究STMs阳性的支气管扩张的临床特征和指标。
方法：回顾性收集2017年1月至2019年12月北京朝阳医院377例支气管扩张患者的临床资料。患者分为STM阴性组，根据STM阳性的数量，分别对单个STM阳性组和≥2个STM阳性组的临床特征进行描述和比较。采用多因素logistic回归分析模型对STMs阳性指标进行调查。
结果：≥2STMs阳性组患者年龄较大（P=0.015），mMRC评分较高（P<0.001），发热较高（P=0.027）。此外,这些患者的白蛋白/球蛋白比值（A/G）也较低，白蛋白（ALB），前白蛋白（PAB）（分别为P<0.001，P<0.001，P<0.001）和较高的CRP，ESR和Fbg（分别为P<0.001，P<0.001和P<0.001）。年龄（OR1.022，95CI1.003-1.042;P=0.026）和受影响的叶数（OR1.443，95CI1.233-1.690;P<0.001）与支气管扩张患者的1个和≥2个阳性STM独立相关。
结论：在支气管扩张患者中，≥2个阳性STMs与更高的炎症状态和更严重的放射学表现相关。
目的：研究STMs阳性的支气管扩张的临床特征和指标。
方法：回顾性收集2017年1月至2019年12月北京朝阳医院377例支气管扩张患者的临床资料。患者分为STM阴性组，根据STM阳性的数量，分别对单个STM阳性组和≥2个STM阳性组的临床特征进行描述和比较。采用多因素logistic回归分析模型对STMs阳性指标进行调查。
结果：≥2STMs阳性组患者年龄较大（P=0.015），mMRC评分较高（P<0.001），发热较高（P=0.027）。此外,这些患者的白蛋白/球蛋白比值（A/G）也较低，白蛋白（ALB），前白蛋白（PAB）（分别为P<0.001，P<0.001，P<0.001）和较高的CRP，ESR和Fbg（分别为P<0.001，P<0.001和P<0.001）。年龄（OR1.022，95CI1.003-1.042;P=0.026）和受影响的叶数（OR1.443，95CI1.233-1.690;P<0.001）与支气管扩张患者的1个和≥2个阳性STM独立相关。
结论：在支气管扩张患者中，≥2个阳性STMs与更高的炎症状态和更严重的放射学表现相关。
