Abstract：
Diabetic cardiomyopathy (DCM) represents a distinct myocardial disorder elicited by diabetes mellitus, characterized by aberrations in myocardial function and structural integrity. This pathological condition predominantly manifests in individuals with diabetes who do not have concurrent coronary artery disease or hypertension. An escalating body of scientific evidence substantiates the pivotal role of programmed cell death (PCD)-encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis-in the pathogenic progression of DCM, thereby emerging as a prospective therapeutic target. Additionally, numerous non-coding RNAs (ncRNAs) have been empirically verified to modulate the biological processes underlying programmed cell death, consequently influencing the evolution of DCM. This review systematically encapsulates prevalent types of PCD manifest in DCM as well as nascent discoveries regarding the regulatory influence of ncRNAs on programmed cell death in the pathogenesis of DCM, with the aim of furnishing novel insights for the furtherance of research in PCD-associated disorders relevant to DCM.
摘要：
糖尿病性心肌病（DCM）代表糖尿病引起的明显的心肌紊乱，以心肌功能和结构完整性异常为特征。这种病理状况主要表现在没有并发冠状动脉疾病或高血压的糖尿病患者中。越来越多的科学证据证实了程序性细胞死亡（PCD）-包括细胞凋亡的关键作用，自噬,焦亡,铁性凋亡,和坏死-在DCM的致病进程中，从而成为一个前瞻性的治疗目标。此外,许多非编码RNA（ncRNAs）已被经验验证，以调节细胞程序性死亡的生物过程，从而影响DCM的演变。这篇综述系统地囊括了DCM中常见的PCD类型，以及关于ncRNAs对DCM发病机理中程序性细胞死亡的调控影响的新生发现。目的是为进一步研究与DCM相关的PCD相关疾病提供新的见解。
