OBJECTIVE: We aimed to detect the concentration of the polyols in participants with and without gestational diabetes mellitus (GDM), and to investigate the association between maternal serum levels of polyols and GDM, as well as newborn outcomes.
METHODS: A nested population-based case-control study was conducted in 109 women with and without GDM. Maternal concentrations of serum erythritol, sorbitol, and xylitol in the fasting state were quantified using a time of flight mass spectrometry system.
RESULTS: In women with GDM, serum concentrations of erythritol and sorbitol were higher, but serum concentrations of xylitol were lower than those in women without GDM. Per 1-SD increment of Box-Cox-transformed concentrations of erythritol and sorbitol were associated with the increased odds of GDM by 43% and 155% (95% CI 1.07-1.92 and 95% CI 1.77-3.69), while decreased odds were found for xylitol by 25% (95% CI 0.57-1.00). Additionally, per 1-SD increase of Box-Cox-transformed concentrations of serum sorbitol was associated with a 52% increased odds of large for gestational age newborns controlling for possible confounders (95% CI 1.00-2.30).
CONCLUSIONS: Maternal circulating sugar alcohols levels during pregnancy were significantly associated with GDM. These findings provide the potential roles of polyols on maternal metabolic health during pregnancy.
目的:我们旨在检测有和没有GDM的参与者中多元醇的浓度,并调查孕妇血清多元醇水平与妊娠期糖尿病(GDM)之间的关系,以及新生儿的结果。
方法:在109名患有和不患有GDM的女性中进行了一项基于人群的巢式病例对照研究。母体血清赤藓糖醇的浓度,山梨醇,和空腹状态的木糖醇使用飞行时间质谱系统进行定量。
结果:在患有GDM的女性中,赤藓糖醇和山梨糖醇的血清浓度较高,但是木糖醇的血清浓度较低,与没有GDM的女性相比。每增加1-SD的Box-Cox转化浓度的赤藓糖醇和山梨糖醇与GDM的几率增加了43%和155%(95%CI1.07-1.92和95CI%:1.77-3.69),而木糖醇的奇数减少了25%(95CI%:0.57-1.00)。此外,Box-Cox转化的血清山梨糖醇浓度每增加1-SD,与控制可能混杂因素的胎龄大新生儿增加52%奇数相关(95%CI1.00-2.30).
结论:妊娠期母体循环糖醇水平与GDM显著相关。这些发现提供了多元醇在怀孕期间对母体代谢健康的潜在作用。