PDF(Pubmed)
Abstract：
UNASSIGNED: Barrett\'s esophagus (BE) is a precursor of esophageal adenocarcinoma. It is critical to recognize the risk factors associated with BE.
UNASSIGNED: The present meta-analysis aims to systematically estimate the association of hiatal hernia with the risk of BE.
UNASSIGNED: A meta-analysis with trial sequential analysis.
UNASSIGNED: The PubMed, EMBASE, and Cochrane Library databases were searched. The pooled odds ratios (ORs) and adjusted ORs (aORs) with their 95% confidence intervals (CIs) were calculated for the combined estimation of unadjusted data and data adjusted for confounders, respectively. Heterogeneity was quantified using the Cochrane Q test and I² statistics. Subgroup, meta-regression, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity.
UNASSIGNED: Forty-seven studies with 131,517 participants were included. Based on the unadjusted data from 47 studies, hiatal hernia was significantly associated with an increased risk of any length BE (OR = 3.91, 95% CI = 3.31-4.62, p < 0.001). The heterogeneity was significant (I² = 77%; p < 0.001) and the definition of controls (p = 0.014) might be a potential contributor to heterogeneity. Based on the adjusted data from 14 studies, this positive association remained (aOR = 3.26, 95% CI = 2.44-4.35, p < 0.001). The heterogeneity was also significant (I² = 65%; p < 0.001). Meta-analysis of seven studies demonstrated that hiatal hernia was significantly associated with an increased risk of long-segment BE (LSBE) (OR = 10.01, 95% CI = 4.16-24.06, p < 0.001). The heterogeneity was significant (I² = 78%; p < 0.001). Meta-analysis of seven studies also demonstrated that hiatal hernia was significantly associated with an increased risk of short-segment BE (OR = 2.76, 95% CI = 2.05-3.71, p < 0.001). The heterogeneity was not significant (I² = 30%; p = 0.201).
UNASSIGNED: Hiatal hernia should be a significant risk factor for BE, especially LSBE.
UNASSIGNED: PROSPERO registration number CRD42022367376.
UNASSIGNED: The present meta-analysis aims to systematically estimate the association of hiatal hernia with the risk of BE.
UNASSIGNED: A meta-analysis with trial sequential analysis.
UNASSIGNED: The PubMed, EMBASE, and Cochrane Library databases were searched. The pooled odds ratios (ORs) and adjusted ORs (aORs) with their 95% confidence intervals (CIs) were calculated for the combined estimation of unadjusted data and data adjusted for confounders, respectively. Heterogeneity was quantified using the Cochrane Q test and I² statistics. Subgroup, meta-regression, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity.
UNASSIGNED: Forty-seven studies with 131,517 participants were included. Based on the unadjusted data from 47 studies, hiatal hernia was significantly associated with an increased risk of any length BE (OR = 3.91, 95% CI = 3.31-4.62, p < 0.001). The heterogeneity was significant (I² = 77%; p < 0.001) and the definition of controls (p = 0.014) might be a potential contributor to heterogeneity. Based on the adjusted data from 14 studies, this positive association remained (aOR = 3.26, 95% CI = 2.44-4.35, p < 0.001). The heterogeneity was also significant (I² = 65%; p < 0.001). Meta-analysis of seven studies demonstrated that hiatal hernia was significantly associated with an increased risk of long-segment BE (LSBE) (OR = 10.01, 95% CI = 4.16-24.06, p < 0.001). The heterogeneity was significant (I² = 78%; p < 0.001). Meta-analysis of seven studies also demonstrated that hiatal hernia was significantly associated with an increased risk of short-segment BE (OR = 2.76, 95% CI = 2.05-3.71, p < 0.001). The heterogeneity was not significant (I² = 30%; p = 0.201).
UNASSIGNED: Hiatal hernia should be a significant risk factor for BE, especially LSBE.
UNASSIGNED: PROSPERO registration number CRD42022367376.
摘要：
■巴雷特食管（BE）是食管腺癌的前兆。认识到与BE相关的危险因素至关重要。
■本荟萃分析旨在系统地评估食管裂孔疝与BE风险的关联。
■采用试验序贯分析的荟萃分析。
■PubMed，EMBASE,搜索了Cochrane图书馆数据库。计算合并的比值比（ORs）和调整后的ORs（aORs）及其95％置信区间（CI），以组合估计未调整数据和针对混杂因素调整后的数据。分别。使用CochraneQ检验和I²统计量量化异质性。子组,元回归，并采用留一敏感性分析来探索异质性的来源。
■纳入了47项研究，有131,517名参与者。根据47项研究的未经调整的数据，食管裂孔疝与任何长度BE的风险增加显著相关(OR=3.91,95%CI=3.31-4.62,p<0.001).异质性是显着的（I²=77％；p<0.001），而对照组的定义（p=0.014）可能是异质性的潜在原因。根据14项研究的调整数据，这种正相关仍然存在(aOR=3.26,95%CI=2.44-4.35,p<0.001).异质性也很显著(I²=65%；p<0.001)。7项研究的荟萃分析表明，食管裂孔疝与长段BE（LSBE）的风险增加显着相关（OR=10.01，95％CI=4.16-24.06，p<0.001）。异质性显著(I²=78%；p<0.001)。对7项研究的荟萃分析还表明，食管裂孔疝与短节段BE的风险增加显着相关（OR=2.76，95％CI=2.05-3.71，p<0.001）。异质性不显著(I²=30%；p=0.201)。
■食管裂孔疝应该是BE的重要危险因素，尤其是LSBE。
■PROSPERO注册号CRD42022367376。
■本荟萃分析旨在系统地评估食管裂孔疝与BE风险的关联。
■采用试验序贯分析的荟萃分析。
■PubMed，EMBASE,搜索了Cochrane图书馆数据库。计算合并的比值比（ORs）和调整后的ORs（aORs）及其95％置信区间（CI），以组合估计未调整数据和针对混杂因素调整后的数据。分别。使用CochraneQ检验和I²统计量量化异质性。子组,元回归，并采用留一敏感性分析来探索异质性的来源。
■纳入了47项研究，有131,517名参与者。根据47项研究的未经调整的数据，食管裂孔疝与任何长度BE的风险增加显著相关(OR=3.91,95%CI=3.31-4.62,p<0.001).异质性是显着的（I²=77％；p<0.001），而对照组的定义（p=0.014）可能是异质性的潜在原因。根据14项研究的调整数据，这种正相关仍然存在(aOR=3.26,95%CI=2.44-4.35,p<0.001).异质性也很显著(I²=65%；p<0.001)。7项研究的荟萃分析表明，食管裂孔疝与长段BE（LSBE）的风险增加显着相关（OR=10.01，95％CI=4.16-24.06，p<0.001）。异质性显著(I²=78%；p<0.001)。对7项研究的荟萃分析还表明，食管裂孔疝与短节段BE的风险增加显着相关（OR=2.76，95％CI=2.05-3.71，p<0.001）。异质性不显著(I²=30%；p=0.201)。
■食管裂孔疝应该是BE的重要危险因素，尤其是LSBE。
■PROSPERO注册号CRD42022367376。
