PDF(Pubmed)
Abstract：
OBJECTIVE: This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.
METHODS: 120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm2) or low dose (0.10 mJ/mm2) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.
RESULTS: High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.
CONCLUSIONS: This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.
METHODS: 120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm2) or low dose (0.10 mJ/mm2) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.
RESULTS: High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.
CONCLUSIONS: This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.
摘要：
目的：这项随机对照试验旨在比较高剂量和低剂量体外冲击波疗法（ESWT）对老年骨关节炎患者免疫系统激活和调节的影响。
方法：120名年龄在65岁及以上的膝骨关节炎患者将被随机分配接受高剂量（0.25mJ/mm2）或低剂量（0.10mJ/mm2）ESWT每周给药4周。血清细胞因子，刺激的免疫细胞亚群，和调节性T细胞将在基线测量，干预后4周和1个月随访。
结果：与低剂量ESWT相比，高剂量ESWT可能是老年骨关节炎患者的主要结局。
结论：本研究将提供有关ESWT给药方案及其差异免疫调节作用的证据，这可以指导老年人群肌肉骨骼疾病的最佳使用。
方法：120名年龄在65岁及以上的膝骨关节炎患者将被随机分配接受高剂量（0.25mJ/mm2）或低剂量（0.10mJ/mm2）ESWT每周给药4周。血清细胞因子，刺激的免疫细胞亚群，和调节性T细胞将在基线测量，干预后4周和1个月随访。
结果：与低剂量ESWT相比，高剂量ESWT可能是老年骨关节炎患者的主要结局。
结论：本研究将提供有关ESWT给药方案及其差异免疫调节作用的证据，这可以指导老年人群肌肉骨骼疾病的最佳使用。
