%0 Journal Article
%T The effects of high and low dose extracorporeal shockwave therapy on immune activation and immunosuppressive markers in elderly patients with osteoarthritis: a study protocol for a randomized controlled trial.
%A Sheng Y
%A Yuan H
%A Chen L
%A Yu B
%J Am J Clin Exp Immunol
%V 12
%N 6
%D 2023
%M 38187367
暂无%X <B>OBJECTIVE: </B>This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.<BR><B>METHODS: </B>120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm2) or low dose (0.10 mJ/mm2) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.<BR><B>RESULTS: </B>High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.<BR><B>CONCLUSIONS: </B>This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.