Abstract：
Food-derived oligopeptides (FOPs) exhibit various bioactivities. However, little was known about their sequence changes in the gastrointestinal tract and the effect of changes on bioactivities. FOPs\' sequence features, changes and effects on bioactivities have been summarised. The sequence length of FOPs decreases with increased exposure of hydrophobic and basic amino acids at the terminal during simulated gastrointestinal digestion. A decrease in bioactivities after simulated intestinal absorption has correlated with a decrease of Leu, Ile, Arg, Tyr, Gln and Pro. The sequence of FOPs that pass readily through the intestinal epithelium corresponds to transport modes, and FOPs whose sequences remain unchanged after transport are the most bioactive. These include mainly dipeptides to tetrapeptides, consisting of numerous hydrophobic and basic amino acids, found mostly at the end of the peptide chain, especially at the C-terminal. This review aims to provide a foundation for applications of FOPs in nutritional supplements and functional foods.
摘要：
食品衍生的寡肽(FOP)表现出各种生物活性。然而,对它们在胃肠道中的序列变化以及变化对生物活性的影响知之甚少。FOP\'序列特征，对生物活性的变化和影响进行了总结。在模拟胃肠道消化过程中，随着末端疏水性和碱性氨基酸暴露的增加，FOP的序列长度减少。模拟肠道吸收后生物活性的降低与Leu的降低相关，Ile,Arg,Tyr,Gln和Pro。容易通过肠上皮的FOP序列对应于运输模式，和FOP，其序列在运输后保持不变是最具生物活性的。这些主要包括二肽到四肽，由许多疏水性和碱性氨基酸组成，主要位于肽链的末端，尤其是在C端。本综述旨在为FOP在营养补充剂和功能食品中的应用提供基础。
