Abstract：
OBJECTIVE: Policosanol is a mixture of long chain alcohols refined from sugar cane. Significant reductions in liver enzymes have been observed in some studies. However, the impact of policosanol on liver enzymes remained controversial. The current meta-analysis aims to evaluate the effect of policosanol supplementation on the levels of alanine transaminase (ALT) and aspartate transaminase (AST).
METHODS: The literature was systematically searched for studies published up to November 2023 in PubMed/Medline, Google Scholar, EMBASE, and Scopus. Randomized controlled trial (RCT) studies were included to evaluate the intervention effect of policosanol compared to placebo on ALT and AST. DerSimonian and Laird models were used to calculate effect sizes.
RESULTS: Twenty-three trials including 2535 participants were included in the study. The combination of effect sizes, regarding the random-effects model, demonstrated significant changes in ALT serum levels after intervention (WMD: -1.48 U/L; 95% CI: -2.33 to -0.64; P = 0.001), and AST (WMD: -1.10 U/L; 95% CI: -1.70 to -0.51; P < 0.001). Subgroup analysis of AST and ALT showed that this reduction effect was most often observed at the dose of 20 mg/d. The dose-response analysis represented a non-significant non-linear connection between the dosage and duration of policosanol intervention in ALT and AST serum reduction.
CONCLUSIONS: Policosanol supplementation exerts a beneficial effect on liver enzymes as well as ALT and AST concentrations in adults. However, further long-term and well-designed RCTs with better quality are needed to further assess and confirm these results.
METHODS: The literature was systematically searched for studies published up to November 2023 in PubMed/Medline, Google Scholar, EMBASE, and Scopus. Randomized controlled trial (RCT) studies were included to evaluate the intervention effect of policosanol compared to placebo on ALT and AST. DerSimonian and Laird models were used to calculate effect sizes.
RESULTS: Twenty-three trials including 2535 participants were included in the study. The combination of effect sizes, regarding the random-effects model, demonstrated significant changes in ALT serum levels after intervention (WMD: -1.48 U/L; 95% CI: -2.33 to -0.64; P = 0.001), and AST (WMD: -1.10 U/L; 95% CI: -1.70 to -0.51; P < 0.001). Subgroup analysis of AST and ALT showed that this reduction effect was most often observed at the dose of 20 mg/d. The dose-response analysis represented a non-significant non-linear connection between the dosage and duration of policosanol intervention in ALT and AST serum reduction.
CONCLUSIONS: Policosanol supplementation exerts a beneficial effect on liver enzymes as well as ALT and AST concentrations in adults. However, further long-term and well-designed RCTs with better quality are needed to further assess and confirm these results.
摘要：
目的：Policosanol是从甘蔗中提炼的长链醇的混合物。在一些研究中已经观察到肝酶的显著降低。然而,policosanol对肝酶的影响仍存在争议.当前的荟萃分析旨在评估补充多酚醇对丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平的影响。
方法：系统搜索了截至2023年11月在PubMed/Medline上发表的研究，谷歌学者，EMBASE,还有Scopus.包括随机对照试验（RCT）研究，以评估与安慰剂相比，多洛沙醇对ALT和AST的干预效果。DerSimonian和Laird模型用于计算效应大小。
结果：这项研究纳入了23项试验，包括2535名参与者。效果大小的组合，关于随机效应模型，显示干预后ALT血清水平显著变化(WMD:-1.48U/L;95%CI:-2.33至-0.64;P=0.001),和AST（WMD：-1.10U/L；95%CI：-1.70至-0.51；P<0.001）。AST和ALT的亚组分析显示,在20mg/d的剂量下最经常观察到这种降低效果。剂量-反应分析表示在ALT和AST血清减少中的多酚醇干预的剂量和持续时间之间的非显著非线性联系。
结论：补充Policosanol对成人的肝酶以及ALT和AST浓度具有有益作用。然而,需要进一步的长期且设计良好且质量更好的RCT来进一步评估和确认这些结果.
方法：系统搜索了截至2023年11月在PubMed/Medline上发表的研究，谷歌学者，EMBASE,还有Scopus.包括随机对照试验（RCT）研究，以评估与安慰剂相比，多洛沙醇对ALT和AST的干预效果。DerSimonian和Laird模型用于计算效应大小。
结果：这项研究纳入了23项试验，包括2535名参与者。效果大小的组合，关于随机效应模型，显示干预后ALT血清水平显著变化(WMD:-1.48U/L;95%CI:-2.33至-0.64;P=0.001),和AST（WMD：-1.10U/L；95%CI：-1.70至-0.51；P<0.001）。AST和ALT的亚组分析显示,在20mg/d的剂量下最经常观察到这种降低效果。剂量-反应分析表示在ALT和AST血清减少中的多酚醇干预的剂量和持续时间之间的非显著非线性联系。
结论：补充Policosanol对成人的肝酶以及ALT和AST浓度具有有益作用。然而,需要进一步的长期且设计良好且质量更好的RCT来进一步评估和确认这些结果.
