PDF(Pubmed)
Abstract：
Mpox is a viral infection caused by the monkeypox virus, a member of the Poxviridae family and Orthopoxvirus genus. Other well-known viruses of the Orthopoxvirus genus include the variola virus (smallpox), cowpox virus and vaccinia virus. Although there is a plethora of research regarding the dermatological and influenza-like symptoms of mpox, particularly following the 2022 mpox outbreak, more research is needed on the gastrointestinal (GI) effects.
This systematic review is to outline the GI manifestations of the monkeypox virus.
The authors conducted this systematic review using guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A search was conducted through the PubMed, EMBASE and MEDLINE databases from January 1958 to June 2023. The authors selected English language papers that discussed the GI symptoms in mpox patients. A manual search was also conducted in the reference sections of these publications for other relevant papers.
33 papers involving 830 patients were selected for this review. The GI manifestations in mpox patients are proctitis, vomiting, diarrhoea, rectal pain, nausea, tenesmus, rectal bleeding and abdominal pain. Although various papers explored transmission routes, one paper established a direct connection between anal-receptive sex transmission route and the development of a GI complication (proctitis). Another study reported that the mode of transmission could potentially impact the occurrence of GI symptoms and severity of the disease. The reviewed papers did not discover a relation between the severity of dermatological and influenza-like symptoms and the GI manifestations mentioned.
This systematic review confirms that GI manifestations are observed in mpox patients. GI symptoms of mpox are crucial for gastroenterologists and other healthcare professionals to recognise in order to address patient discomfort and further understand the pathophysiology of the virus.
This systematic review is to outline the GI manifestations of the monkeypox virus.
The authors conducted this systematic review using guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A search was conducted through the PubMed, EMBASE and MEDLINE databases from January 1958 to June 2023. The authors selected English language papers that discussed the GI symptoms in mpox patients. A manual search was also conducted in the reference sections of these publications for other relevant papers.
33 papers involving 830 patients were selected for this review. The GI manifestations in mpox patients are proctitis, vomiting, diarrhoea, rectal pain, nausea, tenesmus, rectal bleeding and abdominal pain. Although various papers explored transmission routes, one paper established a direct connection between anal-receptive sex transmission route and the development of a GI complication (proctitis). Another study reported that the mode of transmission could potentially impact the occurrence of GI symptoms and severity of the disease. The reviewed papers did not discover a relation between the severity of dermatological and influenza-like symptoms and the GI manifestations mentioned.
This systematic review confirms that GI manifestations are observed in mpox patients. GI symptoms of mpox are crucial for gastroenterologists and other healthcare professionals to recognise in order to address patient discomfort and further understand the pathophysiology of the virus.
摘要：
背景：水痘是由猴痘病毒引起的病毒感染，痘病毒科和正痘病毒属的成员。正痘病毒属的其他众所周知的病毒包括天花病毒（天花），牛痘病毒和牛痘病毒。虽然有大量的关于皮肤科和流感样症状的研究，特别是在2022年水痘爆发之后，需要对胃肠道（GI）的影响进行更多的研究。
目的：本系统综述概述猴痘病毒的胃肠道表现。
方法：作者使用系统评价和荟萃分析的首选报告项目中概述的指南进行了系统评价。通过PubMed进行了搜索，1958年1月至2023年6月的EMBASE和MEDLINE数据库。作者选择了讨论水痘患者胃肠道症状的英文论文。还在这些出版物的参考部分进行了手动搜索，以查找其他相关论文。
结果：选择了涉及830名患者的33篇论文。水痘患者的胃肠道表现是直肠炎，呕吐,腹泻,直肠疼痛,恶心,重弹,直肠出血和腹痛。尽管各种论文探讨了传播途径，一篇论文建立了肛门接受性传播途径与胃肠道并发症(直肠炎)发展之间的直接联系.另一项研究报告说，传播方式可能会影响胃肠道症状的发生和疾病的严重程度。审查的论文没有发现皮肤病和流感样症状的严重程度与提到的胃肠道表现之间的关系。
结论：本系统综述证实，在水痘患者中观察到胃肠道表现。痘痘的胃肠道症状对于胃肠病学家和其他医疗保健专业人员来说是至关重要的，以解决患者的不适并进一步了解病毒的病理生理学。
目的：本系统综述概述猴痘病毒的胃肠道表现。
方法：作者使用系统评价和荟萃分析的首选报告项目中概述的指南进行了系统评价。通过PubMed进行了搜索，1958年1月至2023年6月的EMBASE和MEDLINE数据库。作者选择了讨论水痘患者胃肠道症状的英文论文。还在这些出版物的参考部分进行了手动搜索，以查找其他相关论文。
结果：选择了涉及830名患者的33篇论文。水痘患者的胃肠道表现是直肠炎，呕吐,腹泻,直肠疼痛,恶心,重弹,直肠出血和腹痛。尽管各种论文探讨了传播途径，一篇论文建立了肛门接受性传播途径与胃肠道并发症(直肠炎)发展之间的直接联系.另一项研究报告说，传播方式可能会影响胃肠道症状的发生和疾病的严重程度。审查的论文没有发现皮肤病和流感样症状的严重程度与提到的胃肠道表现之间的关系。
结论：本系统综述证实，在水痘患者中观察到胃肠道表现。痘痘的胃肠道症状对于胃肠病学家和其他医疗保健专业人员来说是至关重要的，以解决患者的不适并进一步了解病毒的病理生理学。
